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CLEC12A

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For Research Use Only. Not For Clinical Use.


Enables pattern recognition receptor activity and transmembrane signaling receptor activity. Involved in several processes, including negative regulation of dendritic cell differentiation; negative regulation of leukocyte activation; and positive regulation of type I interferon production. Is active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A).
Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (monocytes, Macrophages, Kupffer cells)

Immune cell specificity

Immune cell enhanced (eosinophil)

Cell line specificity

Group enriched (HL-60, U-937)

Interaction

Interacts with PTPN6 and PTPN11.

Molecular function

Receptor

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