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    CLEC12A

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
    Protein class

    CD markers

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Group enriched (monocytes, Macrophages, Kupffer cells)

    Immune cell specificity

    Immune cell enhanced (eosinophil)

    Cell line specificity

    Group enriched (HL-60, U-937)

    Interaction

    Interacts with PTPN6 and PTPN11.

    Molecular function

    Receptor

    More Types Infomation
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