Recombinant Anti-CLEC12A Vesicular Antibody, EV Displayed (VS-0425-YC129) (CAT#: VS-0425-YC129)
The Recombinant Anti-CLEC12A Vesicular Antibody, EV Displayed (VS-0425-YC129) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CLEC12A-expressed cells or tissues. The CLEC12A enables pattern recognition receptor activity and is involved in processes such as negative regulation of leukocyte activation and positive regulation of type I interferon production, active in the plasma membrane.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48515/114818_A_7_3.jpg
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48515/114818_A_7_3.jpg
Figure 2 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48515/114818_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48515/114818_A_7_5.jpg
Figure 3 High expression in bone marrow
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48515/114818_B_5_4.jpg
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48515/114818_B_5_4.jpg
Figure 4 RNA cell line category: Group enriched (HL-60, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172322-CLEC12A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172322-CLEC12A
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CLEC12A
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-type lectin domain family 12 member A
- Molecular Function
- Receptor
- Introduction
- Enables pattern recognition receptor activity and transmembrane signaling receptor activity. Involved in several processes, including negative regulation of dendritic cell differentiation; negative regulation of leukocyte activation; and positive regulation of type I interferon production. Is active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A).
- Alternative Names
- Micl; CLL-1; KLRL1; mMICL; mKLRL1; D230024O04
- Gene ID
- 102143884
- UniProt ID
- G7PJS6
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1855z | Mouse Anti-CLEC12A Recombinant Antibody (clone 31C4) | FC | Mouse IgG2b |
| MOB-150CQ | Mouse Anti-CLEC12A Recombinant Antibody (clone YC026) | FC | Mouse IgG2a, κ |
| HPAB-2073LY | Mouse Anti-CLEC12A Recombinant Antibody (HPAB-2073LY) | ELISA, FC | Mouse IgG |
| HPAB-2074LY | Human Anti-CLEC12A Recombinant Antibody (HPAB-2074LY) | ELISA, FC | Human IgG |
| HPAB-1076-FY | Mouse Anti-CLEC12A Recombinant Antibody (HPAB-1076-FY) | Activ | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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