Recombinant Anti-CLEC12A Vesicular Antibody, EV Displayed (VS-0425-YC129)

CAT#: VS-0425-YC129

The Recombinant Anti-CLEC12A Vesicular Antibody, EV Displayed (VS-0425-YC129) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CLEC12A-expressed cells or tissues. The CLEC12A enables pattern recognition receptor activity and is involved in processes such as negative regulation of leukocyte activation and positive regulation of type I interferon production, active in the plasma membrane.

Gene Expression
Figure 1 Colon Figure 2 Kidney Figure 3 High expression in bone marrow Figure 4 RNA cell line category: Group enriched (HL-60, U-937)

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • CLEC12A
  • Host Animal
  • Mouse
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Cynomolgus
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • C-type lectin domain family 12 member A
  • Molecular Function
  • Receptor
  • Introduction
  • Enables pattern recognition receptor activity and transmembrane signaling receptor activity. Involved in several processes, including negative regulation of dendritic cell differentiation; negative regulation of leukocyte activation; and positive regulation of type I interferon production. Is active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A).
  • Alternative Names
  • Micl; CLL-1; KLRL1; mMICL; mKLRL1; D230024O04
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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