Anti-CSF1 Antibody Prodrug, Protease Activated (VS-1025-YC177)
CAT#: VS-1025-YC177
The Anti-CSF1 Antibody Prodrug, Protease Activated (VS-1025-YC177) is an antibody prodrug comprised of a recombinant mouse antibody targeting human CSF1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CSF1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CSF1 effectively. CSF1 (Colony Stimulating Factor 1) is a key cytokine that promotes the recruitment and survival of tumor-associated macrophages (TAMs), which are major components of the immunosuppressive tumor microenvironment. High CSF1 levels are associated with poor prognosis and metastasis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line ASC TERT1
Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, GAMG, HHSteC, HSkMC, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
❮
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human CSF1
- Target
- CSF1
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants.
- Alternative Names
- Colony Stimulating Factor 1 (Macrophage); Lanimostim; CSF-1; MCSF; M-CSF
- Gene ID
- 1435
- UniProt ID
- P09603
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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|---|---|---|---|
| MOB-245-F(E) | Recombinant Anti-human CSF1 Antibody Fab Fragment | WB, RIA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-245-S(P) | Recombinant Anti-human CSF1 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-245 | Recombinant Human Anti-human CSF1 Antibody | ELISA, WB, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-245-F(E) | Recombinant Human Anti-human CSF1 Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-245-S(P) | Recombinant Human Anti-human CSF1 Antibody scFv Fragment | WB, IHC, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-187CL | Human Anti-CSF1 Recombinant Antibody (TAB-187CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1152CT | Recombinant Mouse anti-Human CSF1 Monoclonal antibody | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-501CQ | Mouse Anti-CSF1 Recombinant Antibody (clone 3V17) | Neut, WB | Mouse IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-502CQ | Mouse Anti-CSF1 Recombinant Antibody (clone CBL140) | Neut, WB | Mouse IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-503CQ | Mouse Anti-CSF1 Recombinant Antibody (clone CBL441) | WB, Neut | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-504CQ | Rat Anti-Csf1 Recombinant Antibody (clone 5A1) | Block | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-505CQ | Rat Anti-Csf1 Recombinant Antibody (clone CBL205) | WB, Neut | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-506CQ | Rat Anti-Csf1 Recombinant Antibody (clone CBL535) | WB, Neut | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0824 | Hi-Affi™ Rabbit Anti-CSF1 Recombinant Antibody (clone DS824AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-029ML | Anti-Human CSF1 Recombinant Antibody (TAB-029ML) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0532-CN | Mouse Anti-CSF1 Recombinant Antibody (HPAB-0532-CN) | ELISA, FC, Neut | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0533-CN | Mouse Anti-CSF1 Recombinant Antibody (HPAB-0533-CN) | ELISA, FC, Neut | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0534-CN | Mouse Anti-CSF1 Recombinant Antibody (HPAB-0534-CN) | ELISA, FC, Neut | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0532-CN-S(P) | Mouse Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0532-CN-S(P)) | ELISA, FC, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0533-CN-S(P) | Mouse Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0533-CN-S(P)) | ELISA, FC, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0534-CN-S(P) | Mouse Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0534-CN-S(P)) | ELISA, FC, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0532-CN-F(E) | Mouse Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0532-CN-F(E)) | ELISA, FC, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0533-CN-F(E) | Mouse Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0533-CN-F(E)) | ELISA, FC, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0534-CN-F(E) | Mouse Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0534-CN-F(E)) | ELISA, FC, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-029ML | Afuco™ Anti-CSF1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-029ML) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY96 | Human Anti-CSF1 (clone 1.120.1) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC573 | Recombinant Anti-CSF1 Vesicular Antibody, EV Displayed (VS-0425-YC573) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1704 | Anti-CSF1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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