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    CSF1

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta.
    CSF1
    Protein class

    Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, RAS pathway related proteins

    Predicted location

    Intracellular, Membrane, Secreted (different isoforms)

    Single cell type specificity

    Cell type enhanced (granulocytes, Skeletal myocytes, Sertoli cells, Fibroblasts, Hepatic stellate cells)

    Immune cell specificity

    Group enriched (eosinophil, basophil)

    Cell line specificity

    Cell line enhanced (ASC diff, BJ hTERT+, GAMG, HHSteC, HSkMC, hTERT-RPE1)

    Interaction

    Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

    Molecular function

    Cytokine, Growth factor

    More Types Infomation
    Related Signaling Pathways
    TNF Signaling Pathway TNF Signaling Pathway
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