Recombinant Anti-CSF1 Vesicular Antibody, EV Displayed (VS-0425-YC573) (CAT#: VS-0425-YC573)
The Recombinant Anti-CSF1 Vesicular Antibody, EV Displayed (VS-0425-YC573) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CSF1-expressed cells or tissues. CSF1 is a cytokine that regulates the production, differentiation, and function of macrophages, found extracellularly as a disulfide-linked homodimer. It may also play a role in placental development, produced by proteolytic cleavage of membrane-bound precursors.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
Figure 2 IF staining of human cell line ASC TERT1
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, GAMG, HHSteC, HSkMC, hTERT-RPE1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CSF1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Monkey
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Colony stimulating factor 1
- Biological Process
- Immunity, Inflammatory response, Innate immunity
- Molecular Function
- Cytokine, Growth factor
- Cellular Localization
- Plasma membrane, Nuclear bodies
- Introduction
- The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta.
- Alternative Names
- M-CSF, MCSF, MGC31930
- Gene ID
- 1435
- UniProt ID
- P09603
Related Resources
TNF Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-245-S(P) | Recombinant Human Anti-human CSF1 Antibody scFv Fragment | WB, IHC, FuncS | scFv |
| HPAB-0532-CN-S(P) | Mouse Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0532-CN-S(P)) | ELISA, FC, Neut | Mouse scFv |
| HPAB-0533-CN-S(P) | Mouse Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0533-CN-S(P)) | ELISA, FC, Neut | Mouse scFv |
| HPAB-0150CQ-S(P) | Human Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0150CQ-S(P)) | ELISA, WB, FC, Inhib | Human scFv |
| HPAB-0151CQ-S(P) | Human Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0151CQ-S(P)) | ELISA, WB, FC, Inhib | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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