Recombinant Anti-CSF1 Vesicular Antibody, EV Displayed (VS-0425-YC573)

Name: Recombinant Anti-CSF1 Vesicular Antibody, EV Displayed (VS-0425-YC573)
SKU: VS-0425-YC573
Rating: 5 (1 reviews)

CAT#: VS-0425-YC573

The Recombinant Anti-CSF1 Vesicular Antibody, EV Displayed (VS-0425-YC573) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CSF1-expressed cells or tissues. CSF1 is a cytokine that regulates the production, differentiation, and function of macrophages, found extracellularly as a disulfide-linked homodimer. It may also play a role in placental development, produced by proteolytic cleavage of membrane-bound precursors.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line ASC TERT1

Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg

RNA Expression Figure 4 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, GAMG, HHSteC, HSkMC, hTERT-RPE1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1

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Recombinant Antibody

Application
ELISA, FC, Neut, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
CSF1

Host Animal
Mouse

Antibody Isotype
IgG

Species Reactivity
Human, Monkey

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
Protein A

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
Colony stimulating factor 1

Biological Process
Immunity, Inflammatory response, Innate immunity

Molecular Function
Cytokine, Growth factor

Cellular Localization
Plasma membrane, Nuclear bodies

Introduction
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta.

Alternative Names
M-CSF, MCSF, MGC31930

Gene ID
1435

UniProt ID
P09603

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Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

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Datasheet

Datasheet - VS-0425-YC573.pdf

MSDS

MSDS - VS-0425-YC573.pdf

COA

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