Human Anti-CSF1 (clone 1.120.1) scFv-Fc Chimera
CAT#: VS-0425-FY96
This fusion protein targets CSF1 (M-CSF), a cytokine that regulates the survival, proliferation, and differentiation of monocytes and macrophages. By binding to CSF1, it can modulate the immune response, with potential applications in treating inflammatory and autoimmune diseases where macrophage activity is dysregulated.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
❮
❯
Specifications
- Immunogen
- Human CSF1 as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CSF1
- Species Reactivity
- Human
- Clone
- 1.120.1
- Applications
- Inhibition
- Related Disease
- Soft Tissue Sarcoma and Pigmented Villonodular Synovitis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Colony Stimulating Factor 1; Colony Stimulating Factor 1 (Macrophage); Macrophage Colony Stimulating Factor 1; Lanimostim; CSF-1; MCSF; Macrophage Colony-Stimulating Factor 1; M-CSF
- Gene ID
- 1435
- UniProt ID
- P09603
- Long Name
- Colony Stimulating Factor 1
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- N-glycosylated.
[Isoform 1]: N-glycosylated.
[Isoform 3]: N-glycosylated.
O-glycosylated; contains chondroitin sulfate.
O-glycosylated with core 1 or possibly core 8 glycans.
[Isoform 1]: O-glycosylated.
Glycosylation at Asn154, Asn172, Ser256, Thr257, Thr266, Thr363, Thr365, Thr376, Thr383, Thr387, Ser391, Ser428, Ser430, Ser431, Ser433, Ser451, Ser461, Ser473, and Thr477
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CSF1_HUMAN (2925)
Glycosylation from GlyGen 38 sites, 3 N-linked glycans (1 site), 4 O-linked glycans (34 sites)
- Protein Refseq
- XP_016855858.1; XP_047302708.1; XP_054190514.1; XP_054190515.1; XP_054190516.1
- Function
- Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes.
Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development.
Required for normal male and female fertility.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY96. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 1.120.1"
- CAT
- Product Name
See other products for "CSF1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-187CL | Human Anti-CSF1 Recombinant Antibody (TAB-187CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1152CT | Recombinant Mouse anti-Human CSF1 Monoclonal antibody | ELISA, WB | |
| VS3-QX283 | Mouse Anti-CSF1 Recombinant Antibody (clone 2D10) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-CJ542 | Rabbit Anti-CSF1 Recombinant Antibody (VS3-CJ542) | WB, ICC, IHC, IP | Rabbit IgG |
| VS3-WK1748 | Recombinant Rabbit Anti-CSF1 Capture Antibody (clone R06-2G2) | ELISA | Rabbit IgG |
| VS3-WK1749 | Recombinant Rabbit Anti-CSF1 Detection Antibody (clone R05-8L2) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-501CQ | Mouse Anti-CSF1 Recombinant Antibody (clone 3V17) | Neut, WB | Mouse IgG2 |
| NEUT-502CQ | Mouse Anti-CSF1 Recombinant Antibody (clone CBL140) | Neut, WB | Mouse IgG2 |
| NEUT-503CQ | Mouse Anti-CSF1 Recombinant Antibody (clone CBL441) | WB, Neut | Mouse IgG2a |
| NEUT-505CQ | Rat Anti-Csf1 Recombinant Antibody (clone CBL205) | WB, Neut | Rat IgG2 |
| NEUT-506CQ | Rat Anti-Csf1 Recombinant Antibody (clone CBL535) | WB, Neut | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-504CQ | Rat Anti-Csf1 Recombinant Antibody (clone 5A1) | Block | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0824 | Hi-Affi™ Rabbit Anti-CSF1 Recombinant Antibody (clone DS824AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-029ML | Anti-Human CSF1 Recombinant Antibody (TAB-029ML) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0373-YC-F(E) | Mouse Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0373-YC-F(E)) | Neut | Mouse Fab |
| HPAB-0748-WJ-F(E) | Human Anti-CSF1 Recombinant Antibody (clone 88); Fab Fragment | ELISA, WB, FC | Human Fab |
| HPAB-0749-WJ-F(E) | Human Anti-CSF1 Recombinant Antibody (clone 100); Fab Fragment | ELISA, WB, FC | Human Fab |
| HPAB-0750-WJ-F(E) | Human Anti-CSF1 Recombinant Antibody (clone 3.8.3); Fab Fragment | ELISA, WB, FC | Human Fab |
| HPAB-0751-WJ-F(E) | Human Anti-CSF1 Recombinant Antibody (clone 2.7.3); Fab Fragment | ELISA, WB, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0150CQ-S(P) | Human Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0150CQ-S(P)) | ELISA, WB, FC, Inhib | Human scFv |
| HPAB-0151CQ-S(P) | Human Anti-CSF1 Recombinant Antibody; scFv Fragment (HPAB-0151CQ-S(P)) | ELISA, WB, FC, Inhib | Human scFv |
| HPAB-0748-WJ-S(P) | Human Anti-CSF1 Recombinant Antibody (clone 88); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-0749-WJ-S(P) | Human Anti-CSF1 Recombinant Antibody (clone 100); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-0750-WJ-S(P) | Human Anti-CSF1 Recombinant Antibody (clone 3.8.3); scFv Fragment | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-029ML | Afuco™ Anti-CSF1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-029ML) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC573 | Recombinant Anti-CSF1 Vesicular Antibody, EV Displayed (VS-0425-YC573) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1704 | Anti-CSF1 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, Neut, FuncS
Application: IF, IP, Neut, FuncS, ELISA, FC
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: WB, IHC, FC, Cyt, ELISA
-2.png)
Application: WB, ELISA
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, Neut, FuncS
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: WB, IHC, FC, Cyt, ELISA
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
