Human Anti-CSF1 (clone 1.120.1) scFv-Fc Chimera (CAT#: VS-0425-FY96)
This fusion protein targets CSF1 (M-CSF), a cytokine that regulates the survival, proliferation, and differentiation of monocytes and macrophages. By binding to CSF1, it can modulate the immune response, with potential applications in treating inflammatory and autoimmune diseases where macrophage activity is dysregulated.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1709_G12_12_cr5800dfbe06bb5_selected.jpg
Figure 2 IF staining of human cell line ASC TERT1
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1876_A10_31_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/76624/1769_A4_33_blue_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, GAMG, HHSteC, HSkMC, hTERT-RPE1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184371-CSF1
Specifications
- Immunogen
- Human CSF1 as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CSF1
- Species Reactivity
- Human
- Clone
- 1.120.1
- Applications
- Inhibition
- Related Disease
- Soft Tissue Sarcoma and Pigmented Villonodular Synovitis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Colony Stimulating Factor 1; Colony Stimulating Factor 1 (Macrophage); Macrophage Colony Stimulating Factor 1; Lanimostim; CSF-1; MCSF; Macrophage Colony-Stimulating Factor 1; M-CSF
- Gene ID
- 1435
- UniProt ID
- P09603
- Long Name
- Colony Stimulating Factor 1
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- N-glycosylated.
[Isoform 1]: N-glycosylated.
[Isoform 3]: N-glycosylated.
O-glycosylated; contains chondroitin sulfate.
O-glycosylated with core 1 or possibly core 8 glycans.
[Isoform 1]: O-glycosylated.
Glycosylation at Asn154, Asn172, Ser256, Thr257, Thr266, Thr363, Thr365, Thr376, Thr383, Thr387, Ser391, Ser428, Ser430, Ser431, Ser433, Ser451, Ser461, Ser473, and Thr477
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CSF1_HUMAN (2925)
Glycosylation from GlyGen 38 sites, 3 N-linked glycans (1 site), 4 O-linked glycans (34 sites)
- Protein Refseq
- XP_016855858.1; XP_047302708.1; XP_054190514.1; XP_054190515.1; XP_054190516.1
- Function
- Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes.
Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development.
Required for normal male and female fertility.
Related Resources
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 1.120.1"
See other products for "CSF1"
Select a product category from the dropdown menu below to view related products.
Please select product type
Fab Antibody Products
Human Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
Humanized Antibody Products
IgG Antibody Products
ADCC Enhanced Antibody Products
ScFv Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-245-F(E) | Recombinant Anti-human CSF1 Antibody Fab Fragment | WB, RIA, FuncS | Fab |
| MHH-245-F(E) | Recombinant Human Anti-human CSF1 Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| HPAB-0150CQ-F(E) | Human Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0150CQ-F(E)) | ELISA, WB, FC, Inhib | Human Fab |
| HPAB-0151CQ-F(E) | Human Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0151CQ-F(E)) | ELISA, WB, FC, Inhib | Human Fab |
| HPAB-0110-WJ-F(E) | Human Anti-CSF1 Recombinant Antibody; Fab Fragment (HPAB-0110-WJ-F(E)) | ELISA, FC, WB | Human Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0425-FY96. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: ELISA, WB, BLI, SPR
Application: Block, Cyt, FuncS, Inhib
Application: WB, ELISA, FuncS
Application: FC, ADCC, CDC, Inhib
Application: FC, FRET, Internalization
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, FC, Neut, Inhib
Application: ELISA, FC
Application: ELISA, FC, WB, Inhib, IHC
For Research Use Only. Not For Clinical Use.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
