Recombinant Anti-CSF2 Eliminating Antibody, pH-Sensitive (VS-0625-YC76)
CAT#: VS-0625-YC76
The anti-CSF2 eliminating antibody is an engineered pH-sensitive antibody against human CSF2. CSF2 involves transcription regulation through GTF2H4 protein association. The antibody has a novel CSF2-sweeping activity in vivo, which selectively eliminatesthe soluble CSF2 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57404/1703_H9_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (BJ hTERT+)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164400-CSF2
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Specifications
- Host Species
- Human
- Type
- Human IgG1 kappa
- Specificity
- Human CSF2
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-478 | Human Anti-CSF2 Recombinant Antibody (clone MB007); Fab Fragment | Neut | Human Fab |
| HPAB-0014-FY-F(E) | Human Anti-CSF2 Recombinant Antibody Fab Fragment (HPAB-0014-FY-F(E)) | ELISA | Human Fab |
| HPAB-0136-FY-F(E) | Human Anti-CSF2 Recombinant Antibody (clone MSB-0010628); Fab Fragment | Inhib | Humanized Fab |
| PFBC-337 | Human Anti-CSF2 Recombinant Antibody (clone F1); Fab Fragment | ELISA, FC, Neut | Human Fab |
| PFBC-338 | Mouse Anti-CSF2 Recombinant Antibody (clone 4D4); Fab Fragment | ELISA, FC, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-478 | Human Anti-CSF2 Recombinant Antibody (clone MB007); scFv Fragment | Neut | Human scFv |
| HPAB-0136-FY-S(P) | Human Anti-CSF2 Recombinant Antibody (clone MSB-0010628); scFv Fragment | Inhib | Humanized scFv |
| HPAB-1090-FY-F(E) | Human Anti-CSF2 Recombinant Antibody; Fab Fragment (HPAB-1090-FY-F(E)) | ELISA | Human Fab |
| HPAB-1091-FY-F(E) | Human Anti-CSF2 Recombinant Antibody; Fab Fragment (HPAB-1091-FY-F(E)) | ELISA | Human Fab |
| HPAB-1092-FY-F(E) | Human Anti-CSF2 Recombinant Antibody; Fab Fragment (HPAB-1092-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-177CT | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (KB002) | ELISA, Neut | Human antibody |
| TAB-178CT | Human Anti-CSF2 Recombinant Antibody (TAB-178CT) | ELISA, Neut, FC, WB | Human IgG1, κ |
| TAB-179CT | Human Anti-CSF2 Recombinant Antibody (TAB-179CT) | ELISA, WB, Neut | Human IgG1, κ |
| TAB-180CT | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (F1) | Neut, Inhib, FC, ELISA | Human antibody |
| TAB-181CT | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (C3) | Neut, SPR, Inhib, ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-183CT | Mouse Anti-CSF2 Recombinant Antibody (TAB-183CT) | ELISA, FC, WB, Block | Mouse IgG |
| TAB-185CT | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (4K21) | ELISA, Neut | |
| TAB-183CT-S(P) | Mouse Anti-CSF2 Recombinant Antibody; scFv Fragment (TAB-183CT-S(P)) | ELISA, FC, WB, Block | Mouse scFv |
| TAB-185CT-S(P) | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody scFv Fragment (4K21) | ELISA, Neut | |
| TAB-183CT-F(E) | Mouse Anti-CSF2 Recombinant Antibody; Fab Fragment (TAB-183CT-F(E)) | ELISA, FC, WB, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-184CT | Human Anti-CSF2 Recombinant Antibody (TAB-184CT) | ELISA, FC, WB, Block | Chimeric (Mouse/Human) IgG1, κ |
| TAB-184CT-S(P) | Human Anti-CSF2 Recombinant Antibody; scFv Fragment (TAB-184CT-S(P)) | ELISA, FC, WB, Block | Human scFv |
| TAB-184CT-F(E) | Human Anti-CSF2 Recombinant Antibody; Fab Fragment (TAB-184CT-F(E)) | ELISA, FC, WB, Block | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-186CT | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (hGM4/1-34) | ELISA, Neut | Humanized antibody |
| TAB-186CT-S(P) | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody scFv Fragment (hGM4/1-34) | ELISA, Neut | Humanized antibody |
| TAB-186CT-F(E) | Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody Fab Fragment (hGM4/1-34) | ELISA, Neut | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-511CQ | Recombinant Mouse Anti-CSF2 Antibody (CBL568) | Neut | IgG1 |
| NEUT-513CQ | Rat Anti-CSF2 Recombinant Antibody (clone 23B6) | Neut | Rat IgG2a |
| NEUT-515CQ | Mouse Anti-CSF2 Recombinant Antibody (NEUT-515CQ) | IHC, Neut, WB | Mouse IgG1 |
| NEUT-516CQ | Mouse Anti-CSF2 Recombinant Antibody (clone BVD2-21C11) | Neut, FC, ICC, IF, WB, IP, IHC-Fr | Mouse IgG2a, κ |
| NEUT-517CQ | Rat Anti-CSF2 Recombinant Antibody (clone BVD2-23B6) | ELISA, FC, IP, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-512CQ | Rat Anti-CSF2 Recombinant Antibody (clone 22E9), Biotin | Block, ELISA, WB | Rat IgG2a |
| NEUT-514CQ | Rat Anti-CSF2 Recombinant Antibody (clone 31G6) | Block, ELISA, WB | Rat IgG1 |
| NEUT-525CQ | Rat Anti-Csf2 Recombinant Antibody (clone CBL251) | Inhib | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4580 | Hi-Affi™ Rabbit Anti-CSF2 Recombinant Antibody (clone TH92DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-259 | Afuco™ Anti-CSF2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-259) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-H44 | Afuco™ Anti-CSF2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H44) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-105CQ | Rat Anti-Csf2 Recombinant Antibody (clone MP1-22E9) | ELISA, Neut, WB | Rat IgG2a |
| HPAB-1090-FY | Human Anti-CSF2 Recombinant Antibody (HPAB-1090-FY) | ELISA | Human IgG |
| HPAB-1091-FY | Human Anti-CSF2 Recombinant Antibody (HPAB-1091-FY) | ELISA | Human IgG |
| FAMAB-1100CQ | Human Anti-CSF2 Recombinant Antibody (clone GCC21) | Neut, ELISA | Human IgG1 |
| VS3-XY537 | Mouse Anti-CSF2 Recombinant Antibody (clone 3D3) | ELISA, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY70 | AbPlus™ Anti-CSF2 Magnetic Beads (BVD2-21C11) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY98 | Human Anti-CSF2 (clone MSB-0010628) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1707 | Anti-CSF2 Immunohistochemistry Kit | IHC |
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