Is this antibody suitable for neutralization?

Yes, the Anti-Human CSF2 Recombinant Antibody (TAB-259) has been reported for use in Neutralization (Neut) assays. It binds to native human antigen and can modulate the activity of GM-CSF. It is also validated for IP, IF, FC, ELISA, and ICC.

What is the host and isotype?

This is a Human IgG1, kappa monoclonal antibody. It is produced in CHO cells to ensure high quality and consistency. The purity is greater than 95% as determined by SDS-PAGE analysis.

Anti-Human CSF2 Recombinant Antibody (TAB-259)

CAT#: TAB-259

Recombinant monoclonal antibody to CSF2. It is an immunomodulator. It binds to reticulon 4.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line BJ

Immunofluorescent staining of human cell line A-431 shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57404/1703_H9_1_selected.jpg

RNA Expression Figure 2 RNA cell line category: Cell line enriched (BJ hTERT+)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164400-CSF2

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Specifications

Immunogen
Recombinant full length protein (Mouse) expressed in yeast.

Host Species
Human

Derivation
Human

Type
IgG1 - kappa

Specificity
Tested positive against native human antigen.

Species Reactivity
Human

Applications
IP, IF, FuncS, FC, Neut, ELISA, ICC

Related Disease
Rheumatoid arthritis (RA)

Product Property

Purity
>95.0% as determined by analysis by SDS-PAGE.

Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Applications

Application Notes
The CSF2 antibody has been reported in applications of PK , Inhib.

Target

Alternative Names
Colony Stimulating Factor 2; Molgramostin; Colony Stimulating Factor 2 (Granulocyte-Macrophage); GMCSF; CSF

Gene ID
1437

UniProt ID
P04141

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Breast cancer biomarkers at key points during disease progression

Effective GM-CSF Neutralization

We used this Anti-Human CSF2 Recombinant Antibody (TAB-259) in neutralization assays. It effectively inhibited the biological activity of GM-CSF in our cell culture model. It is a Human IgG1 antibody with high purity (>95%), which gave us confidence in our functional data.

Versatile Research Tool

This antibody is validated for so many applications. We tried it in IP and ICC, and it worked well in both. It binds to the native human antigen. We appreciate that it is available in a larger 1mg size, which is great for our high-volume experiments.

Q&As

Is this antibody suitable for neutralization?

A: Yes, the Anti-Human CSF2 Recombinant Antibody (TAB-259) has been reported for use in Neutralization (Neut) assays. It binds to native human antigen and can modulate the activity of GM-CSF. It is also validated for IP, IF, FC, ELISA, and ICC.
What is the host and isotype?

A: This is a Human IgG1, kappa monoclonal antibody. It is produced in CHO cells to ensure high quality and consistency. The purity is greater than 95% as determined by SDS-PAGE analysis.

View the frequently asked questions answered by Creative Biolabs Support.

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Biosimilar Overview

Please refer to Namilumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Namilumab.

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-259.pdf

MSDS

MSDS - TAB-259.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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