Mouse Anti-CX3CR1 Recombinant Antibody (VS3-FY2681)
CAT#: VS3-FY2681
This anti-CX3CR1 mAb is a mouse recombinant antibody that is created to recognize CX3CR1. The calculated molecular weight of the protein is 40.4 kDa. It exhibits cross-reactivity with human. This monoclonal antibody is potential for conducting research on Macular Degeneration, Age-Related, 12 and human Immunodeficiency Virus Type 1. The antibody can be utilized for detection of CX3CR1 by Immunocytochemistry, Flow cytometry, ELISA.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/1813_G11_17_cr59f1a1656f54b_selected.jpg
Normal Tissue
Figure 2 IHC staining of human caudate
Immunohistochemical staining of human caudate shows distinct positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong positivity in a subsets of cells outside reaction centra.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32478/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_6_6.jpg
Normal Tissue
Figure 9 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enriched (RPMI-8226)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168329-CX3CR1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- C-X3-C motif chemokine receptor 1 of human
- Species Reactivity
- Human
- Applications
- ICC, FC, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 40.4 kDa.
- Related Disease
- Macular Degeneration, Age-Related, 12 and Human Immunodeficiency Virus Type 1
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunocytochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- C-X3-C Motif Chemokine Receptor 1; Chemokine (C-X3-C Motif) Receptor 1; Beta Chemokine Receptor-Like 1; Chemokine (C-X3-C) Receptor 1; G-Protein Coupled Receptor 13; Fractalkine Receptor; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1
- Gene ID
- 1524
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_047303494.1; XP_054201399.1; NP_001164642.1; NP_001164643.1; NP_001164645.1
- Function
- Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (By similarity).
Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (By similarity).
Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (By similarity).
Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:14581400, 18971423).
Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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