Mouse Anti-CX3CR1 Recombinant Antibody (VS3-FY2681) (CAT#: VS3-FY2681)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• C-X3-C motif chemokine receptor 1 of human

• Species Reactivity
• Human

• Applications
• ICC, FC, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 40.4 kDa.

• Related Disease
• Macular Degeneration, Age-Related, 12 and Human Immunodeficiency Virus Type 1

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunocytochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• C-X3-C Motif Chemokine Receptor 1; Chemokine (C-X3-C Motif) Receptor 1; Beta Chemokine Receptor-Like 1; Chemokine (C-X3-C) Receptor 1; G-Protein Coupled Receptor 13; Fractalkine Receptor; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1

• Gene ID
• 1524

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• XP_047303494.1; XP_054201399.1; NP_001164642.1; NP_001164643.1; NP_001164645.1

• Function
• Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (By similarity).
  Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (By similarity).
  Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (By similarity).
  Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:14581400, 18971423).
  Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (By similarity).

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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