Mouse Anti-CX3CR1 Recombinant Antibody (VS3-FY2681) (CAT#: VS3-FY2681)
This anti-CX3CR1 mAb is a mouse recombinant antibody that is created to recognize CX3CR1. The calculated molecular weight of the protein is 40.4 kDa. It exhibits cross-reactivity with human. This monoclonal antibody is potential for conducting research on Macular Degeneration, Age-Related, 12 and human Immunodeficiency Virus Type 1. The antibody can be utilized for detection of CX3CR1 by Immunocytochemistry, Flow cytometry, ELISA.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/1813_G11_17_cr59f1a1656f54b_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/1813_G11_17_cr59f1a1656f54b_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows distinct positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/ihc_selected.jpg
(Immunohistochemical staining of human caudate shows distinct positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong positivity in a subsets of cells outside reaction centra.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32478/ihc_selected.jpg
(Immunohistochemical staining of human tonsil shows strong positivity in a subsets of cells outside reaction centra.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32478/ihc_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_B_8_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_B_8_5.jpg
Figure 5 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_9_3.jpg
Figure 6 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_9_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_9_4.jpg
Figure 7 Kidney
(Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_8_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_8_5.jpg
Figure 8 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_6_6.jpg
Figure 9 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_8_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46587/139613_A_8_8.jpg
Figure 10 RNA cell line category: Cell line enriched (RPMI-8226)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168329-CX3CR1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168329-CX3CR1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- C-X3-C motif chemokine receptor 1 of human
- Species Reactivity
- Human
- Applications
- ICC, FC, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 40.4 kDa.
- Related Disease
- Macular Degeneration, Age-Related, 12 and Human Immunodeficiency Virus Type 1
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunocytochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- C-X3-C Motif Chemokine Receptor 1; Chemokine (C-X3-C Motif) Receptor 1; Beta Chemokine Receptor-Like 1; Chemokine (C-X3-C) Receptor 1; G-Protein Coupled Receptor 13; Fractalkine Receptor; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1
- Gene ID
- 1524
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_047303494.1; XP_054201399.1; NP_001164642.1; NP_001164643.1; NP_001164645.1
- Function
- Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (By similarity).
Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (By similarity).
Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (By similarity).
Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:14581400, 18971423).
Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (By similarity).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CX3CR1"
Select a product category from the dropdown menu below to view related products.
Please select product type
Chicken IgY Antibody Products
Neutralizing Antibody Products
Single Domain Antibody Products
IgG Antibody Products
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0146MZ | Chicken Anti-CX3CR1 Polyclonal IgY | indirect ELISA, WB | Chicken antibody |
| BRD-0988MZ | Chicken Anti-CX3CR1 Polyclonal IgY | ELISA, WB | Chicken antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS3-FY2681. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: ELISA, WB, BLI, SPR
Application: ELISA, FuncS
Application: FC, IHC, Cyt, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
