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CX3CR1

Anti-CX3CR1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
Protein class

Disease related genes, G-protein coupled receptors, Human disease related genes, Plasma proteins, Potential drug targets

Predicted location

Membrane

Single cell type specificity

Group enriched (NK-cells, Microglial cells)

Immune cell specificity

Immune cell enhanced (non-classical monocyte)

Cell line specificity

Cell line enriched (RPMI-8226)

Interaction

Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1. (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. (Microbial infection) Interacts with HIV-1 envelope polyprotein gp160.

Molecular function

G-protein coupled receptor, Receptor, Transducer

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