Anti-CX3CR1 Products

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For Research Use Only. Not For Clinical Use.

Partner with Creative Biolabs, your neuroscience and immunology expert, to access high specificity anti-CX3CR1 recombinant antibodies. CX3CR1 is the only receptor for the chemokine Fractalkine. As such, CX3CR1 tightly regulates microglial localization and inflammatory state in the brain. Our high-quality antibodies are critical tools for studying neuroinflammation and the pathogenesis of Alzheimer's and Parkinson's disease.

CX3CR1: The Microglia-Specific Chemokine Receptor

CX3CR1, or C-X3-C motif chemokine receptor 1, is a G protein-coupled receptor (GPCR) that is strongly and selectively expressed on certain immune cell populations, including monocytes, NK cells, and most prominently, CNS-resident microglia. Its unique ligand CX3CL1 (also known as Fractalkine) is the only chemokine that is often expressed in its membrane-tethered form on the surface of neurons. The CX3CR1-CX3CL1 axis thus mediates crosstalk between neurons and microglia. Signaling through CX3CR1 keeps microglia in a quiescent, tissue surveilling state. Mutations that result in loss of CX3CR1 function lead to an increased risk of neurodegenerative disease. Thus, this pathway is critical for brain health.

Alternative Names

C-X3-C Motif Chemokine Receptor 1; Chemokine (C-X3-C Motif) Receptor 1

Background

CX3CR1 (C-X3-C Motif Chemokine Receptor 1) is a Protein Coding gene. Macular Degeneration, Age-Related, 12 and Human Immunodeficiency Virus Type 1 are associated with CX3CR1. The pathways, Akt Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers, are linked to this gene. GO annotations that are related to this gene include G-protein coupled receptor activity and chemokine receptor activity.

Anti-CX3CR1 rAb Products

Creative Biolabs anti-CX3CR1 recombinant antibodies are engineered for optimal affinity and specificity. We extensively validate all our anti-CX3CR1 rAbs for robust detection of CX3CR1 on the surface of primary immune cells and microglia. Further, we optimize our rAbs for key applications such as multi-color flow cytometry for cell sorting, IHC on brain sections, and functional blocking of Fractalkine binding, making our rAbs premier tools for studying neuroinflammation.

Table 1. Featured anti-CX3CR1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs leverages state-of-the-art production technologies to support innovative neuroinflammation research. Our anti-CX3CR1 recombinant antibodies are carefully designed to specifically recognize the native conformation of extracellular domains on the receptor, ensuring high functional activity.

Featured Anti-CX3CR1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CX3CR1 recombinant antibody production.

Fig.2 Gram-scale anti-CX3CR1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing our customers with innovative and flexible solutions to meet your needs. We offer anti-CX3CR1 recombinant antibodies in a wide range of customizable modalities, including functional blocking clones, to help researchers around the globe study this critical receptor.

Fig.3 Full-length anti-CX3CR1 recombinant antibody production and modalities.

CX3CR1-Targeted Drug Information

Table 2. Public drug targeting CX3CR1.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Power your neuroinflammation research with Creative Biolabs' anti-CX3CR1 recombinant antibodies. We are defined by our high specificity and functional validation. All of our tools are rigorously vetted to ensure that you have the ideal antibody or peptide for both basic research and drug development. Let us help you in your critical work. Contact our experts today.