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CX3CR1
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Plasma proteins, Potential drug targets
Predicted location
Membrane
Single cell type specificity
Group enriched (NK-cells, Microglial cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Cell line enriched (RPMI-8226)
Interaction
Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1. (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. (Microbial infection) Interacts with HIV-1 envelope polyprotein gp160.
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
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- Species Reactivity: Mouse
- Type: Mouse IgG2a, κ
- Application: FC
- Chicken Anti-CX3CR1 Polyclonal IgY (BRD-0146MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: indirect ELISA, WB
- Chicken Anti-CX3CR1 Polyclonal IgY (BRD-0988MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: ELISA, WB
- Llama Anti-CX3CR1 Recombinant Antibody (HPAB-0624-CN) (HPAB-0624-CN)
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- Derivation: VHH phage display library
- Species Reactivity: Human
- Type: Llama VHH
- Application: ELISA, FC, BL
- Llama Anti-CX3CR1 Recombinant Antibody (HPAB-0623-CN) (HPAB-0623-CN)
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- Derivation: VHH phage display library
- Species Reactivity: Human, Cynomolgus monkey
- Type: Llama VHH
- Application: ELISA, FC, BL
- Llama Anti-CX3CR1 Recombinant Antibody (HPAB-0622-CN) (HPAB-0622-CN)
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- Derivation: VHH phage display library
- Species Reactivity: Human, Cynomolgus monkey
- Type: Llama VHH
- Application: ELISA, FC, BL
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For Research Use Only. Not For Clinical Use.