Mouse Anti-CX3CR1 scFv-Fc Chimera (VS-0625-FY6) (CAT#: VS-0625-FY6)

• Immunogen
• The antibodies for mCX3CR1 was generated by immunizing CX3CR1 knockout mice with Jurkat cells transfected with mCX3CR1.

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• The anti-mCX3CR1 monoclonal antibody binds to cell surface-expressed mCX3CR1 (mouse CX3CR1).

• Species Reactivity
• Mouse

• Applications
• Blocking, Flow Cytometry

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Blocking: 2 ug/mL
  Flow Cytometry: 10 ug/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• C-X3-C Motif Chemokine Receptor 1; Chemokine (C-X3-C Motif) Receptor 1; Beta Chemokine Receptor-Like 1; Chemokine (C-X3-C) Receptor 1; G-Protein Coupled Receptor 13; Fractalkine Receptor; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1

• Gene ID
• 1524

• UniProt ID
• P49238

• Long Name
• C-X3-C Motif Chemokine Receptor 1

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• XP_047303494.1; XP_054201399.1; NP_001164642.1; NP_001164643.1; NP_001164645.1

• Function
• Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (By similarity).
  Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (By similarity).
  Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (By similarity).
  Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:14581400, 18971423).
  Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (By similarity).

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