Recombinant Anti-CXCL10 Eliminating Antibody, pH-Sensitive (VS-0625-YC81)
CAT#: VS-0625-YC81
The anti-CXCL10 eliminating antibody is an engineered pH-sensitive antibody against human CXCL10. CXCL10 is a cytokine of the CXC family, involved in immune induction. The antibody has a novel CXCL10-sweeping activity in vivo, which selectively eliminatesthe soluble CXCL10 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, GAMG, RPMI-8226, RT4, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169245-CXCL10
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Specifications
- Host Species
- Human
- Type
- Human IgG1 kappa
- Specificity
- Human CXCL10
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-0580CL | Mouse Anti-CXCL10 Recombinant Antibody (TAB-0580CL) | WB, ELISA | Mouse IgG |
| TAB-0581CL | Mouse Anti-CXCL10 Recombinant Antibody (TAB-0581CL) | WB, ELISA | Mouse IgG |
| TAB-0582CL | Mouse Anti-CXCL10 Recombinant Antibody (TAB-0582CL) | WB, ELISA | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| HPAB-AP614-YC-S(P) | Human Anti-CXCL10 Recombinant Antibody (clone 10E); scFv Fragment | ELISA, WB, Inhib | Human scFv |
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| HPAB-AP616-YC-S(P) | Human Anti-CXCL10 Recombinant Antibody (clone 12D); scFv Fragment | ELISA | Human scFv |
| HPAB-AP617-YC-S(P) | Human Anti-Cxcl10 Recombinant Antibody (clone 2A); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1676-FY-S(P) | Human Anti-CXCL10 Recombinant Antibody; scFv Fragment (HPAB-1676-FY-S(P)) | Inhib, ELISA, FC | Human scFv |
| HPAB-1677-FY-S(P) | Human Anti-CXCL10 Recombinant Antibody; scFv Fragment (HPAB-1677-FY-S(P)) | Inhib, ELISA, FC | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| VS-0325-XY591 | Anti-CXCL10 Immunohistochemistry Kit | IHC | |
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| CAT | Product Name | Application | Type |
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