Recombinant Anti-CXCL12 Eliminating Antibody, pH-Sensitive (hu30D8 var.)
CAT#: VS-0625-YC82
The anti-CXCL12 eliminating antibody is an engineered pH-sensitive antibody against human and mouse CXCL12. CXCL12 regulates diverse cellular roles and is linked to HIV resistance. The antibody has a novel CXCL12-sweeping activity in vivo, which selectively eliminatesthe soluble CXCL12 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_B_7_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_A_6_6.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17564/39207_B_4_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107562-CXCL12
❮
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG
- Specificity
- Human and Mouse CXCL12
- Species Reactivity
- Human, Mouse
- Clone
- hu30D8 var.
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256 | Recombinant Anti-human CXCL12 Antibody | ELISA, WB, FC, FuncS | IgG |
| MHH-256 | Recombinant Human Anti-human CXCL12 Antibody | ELISA, WB, FuncS | IgG |
| HPAB-632-FY | Human Anti-CXCL12 Recombinant Antibody (HPAB-632-FY) | Inhib | Chimeric (Mouse/Human) IgG2a |
| HPAB-633-FY | Human Anti-CXCL12 Recombinant Antibody (HPAB-633-FY) | Block | Chimeric (Mouse/Human) IgG2a |
| VS3-CJ980 | Rabbit Anti-CXCL12 Recombinant Antibody (VS3-CJ980) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256-F(E) | Recombinant Anti-human CXCL12 Antibody Fab Fragment | IF, FACS, FuncS | Fab |
| MHH-256-F(E) | Recombinant Human Anti-human CXCL12 Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
| PFBL-057 | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (PFBL-057) | FC, ELISA, FuncS | Human Fab |
| HPAB-632-FY-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-632-FY-F(E)) | Inhib | Chimeric (Mouse/Human) Fab |
| HPAB-633-FY-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-633-FY-F(E)) | Block | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256-S(P) | Recombinant Anti-human CXCL12 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| HPAB-0050LY-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0050LY-S(P)) | Block, ELISA, WB, RIA, FC | Human scFv |
| HPAB-0051LY-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0051LY-S(P)) | Block, ELISA, WB, RIA, FC | Human scFv |
| HPAB-632-FY-S(P) | Mouse Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-632-FY-S(P)) | Inhib | Mouse scFv |
| HPAB-633-FY-S(P) | Mouse Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-633-FY-S(P)) | Block | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-040 | Recombinant Anti-Human CXCL12 VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
| HPAB-0348-YC-VHH | Llama Anti-CXCL12 Recombinant Antibody; VHH Fragment (HPAB-0348-YC-VHH) | FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-415CT | Anti-Human CXCL12 Recombinant Antibody (30D8) | Inhib, WB, FC, Funcs, ELISA, Neut | |
| TAB-415CT-S(P) | Anti-Human CXCL12 Recombinant Antibody scFv Fragment (30D8) | WB, ELISA, Neut, FC | |
| TAB-415CT-F(E) | Anti-Human CXCL12 Recombinant Antibody Fab Fragment (30D8) | WB, ELISA, Neut, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-416CT | Anti-Human CXCL12 Recombinant Antibody (hu30D8) | Funcs, FC, PK, ELISA, Neut, WB | Humanized antibody |
| TAB-416CT-S(P) | Anti-Human CXCL12 Recombinant Antibody scFv Fragment (hu30D8) | WB, ELISA, Neut, FC | Humanized antibody |
| TAB-416CT-F(E) | Anti-Human CXCL12 Recombinant Antibody Fab Fragment (hu30D8) | WB, ELISA, Neut, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-417CT-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (TAB-417CT-S(P)) | BL, WB, ELISA | Human scFv |
| TAB-417CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-417CT-F(E)) | BL, WB, ELISA | Human Fab |
| TAB-418CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-418CT-F(E)) | BL, WB, ELISA | Human Fab |
| TAB-419CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-419CT-F(E)) | BL, WB, ELISA | Human Fab |
| TAB-420CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-420CT-F(E)) | BL, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-612CQ | Mouse Anti-CXCL12 Recombinant Antibody (clone CBL825) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0884 | Hi-Affi™ Rabbit Anti-CXCL12 Recombinant Antibody (clone DS884AB) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY17 | Hamster Anti-CXCL12 scFv-Fc Chimera (VS-0425-FY17) | ELISA, Block | Hamster IgG, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1813 | Anti-CXCL12 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1814 | Anti-Rat CXCL12 Immunohistochemistry Kit | IHC |
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