Human Anti-CXCL8 Recombinant Antibody (clone WS-4) (CAT#: HPAB-1841-FY)
This product is a recombinant antibody that recognizes CXCL8. The monoclonal antibody WS-4 reacts with the epitope of CXCL8. WS-4 has been shown to inhibit the binding of rabbit IL-8 to rabbit neutrophils by Harada.
Specific Inquiry
Inhib
Figure 1 Survival curves for the 12 hour observation period.
Fifty per cent of the untreated rabbits were alive at 9 h and only 40% at 12h, whereas 90% of WS-4 treated rabbits were alive at 12h (p<0.05).
Osman, M., Kristensen, J., Jacobsen, N., Lausten, S., Deleuran, B., Deleuran, M., ... & Jensen, S. (1998). A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits. Gut, 43(2), 232.
Inhib
Figure 2 Serum TNF-α concentrations detection.
Showing a biphasic curve in controls with peaks at 3 and 9 h. Pretreatment with WS-4 resulted in a significant reduction in TNF-Æ concentrations from 3 to 9 h.
Osman, M., Kristensen, J., Jacobsen, N., Lausten, S., Deleuran, B., Deleuran, M., ... & Jensen, S. (1998). A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits. Gut, 43(2), 232.
ELISA
Figure 3 Shows a graph showing a result of ELISA for confirmation of an ability to bind to human IL-8 of the chimeric WS-4 antibody (chL/chH) produced in the supernatant of COS cells.
Block
Figure 4 Shows a graph showing the results of a receptor binding inhibition assay.
This assay tests the ability of purified control human IgG, a chimeric antibody (chL/chH), reshaped antibodies (RVLa/RVHg and RVLb/RVHg) and the original WS-4 antibody to block binding of IL-8 to its receptor.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG
- Specificity
- Human CXCL8
- Species Reactivity
- Human
- Clone
- WS-4
- Applications
- Inhib, FC, ELISA, Block
- Related Disease
- Crohn's Disease, inflammatory bowel disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CXCL8 antibody has been reported in applications of Inhibition, Flow Cytometry, Enzyme-linked Immunosorbent Assay, Blocking.
Target
- Alternative Names
- IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; interleukin-8; T-cell chemotactic factor; alveolar macrophage chemotactic factor I; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; emoctakin; granulocyte chemotactic protein 1; interleukin 8; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; tumor necrosis factor-induced gene 1
- Gene ID
- 3576
- UniProt ID
- P10145
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone WS-4"
See other products for "CXCL8"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-738-sdAb | Recombinant Anti-human CXCL8 VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201CL | Human Anti-CXCL8 Recombinant Antibody (TAB-201CL) | ELISA | Human IgG2 |
| TAB-701LC | Human Anti-CXCL8 Recombinant Antibody (TAB-701LC) | ELISA, FC, FuncS | Human IgG1, κ |
| TAB-701LC-S(P) | Human Anti-CXCL8 Recombinant Antibody; scFv Fragment (TAB-701LC-S(P)) | ELISA | Human scFv |
| TAB-701LC-F(E) | Human Anti-CXCL8 Recombinant Antibody; Fab Fragment (TAB-701LC-F(E)) | ELISA | Human Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-095LC | Recombinant Anti-Human CXCL8 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-164LC | Recombinant Anti-Human CXCL8 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-644CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL601) | ELISA, Neut | Mouse IgG1 |
| NEUT-645CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL602) | WB, ICC, Neut | Mouse IgG1 |
| NEUT-646CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL115) | FC, WB, IHC, Neut | Mouse IgG1 |
| NEUT-647CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone I8-60) | ELISA, Neut, WB | Mouse IgG1, κ |
| NEUT-648CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone I8-S2) | ELISA, Neut, WB | Mouse IgG2b, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-660CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone B-K8) | Block, ICFC | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4128 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone SI199DS) | ELISA | Rabbit IgG |
| MOR-4624 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone TH137DS) | WB | Rabbit IgG |
| MOR-4625 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone TH138DS) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1973-CN | Rabbit Anti-CXCL8 Polyclonal Antibody (MRO-1973-CN) | ELISA, IF, IHC | Rabbit IgG |
| MRO-1974-CN | Rabbit Anti-CXCL8 Polyclonal Antibody (MRO-1974-CN) | WB, IF, FC | Rabbit IgG |
| HPAB-1101-FY | Mouse Anti-CXCL8 Recombinant Antibody (clone 656.35) | ELISA, IA, Block | Mouse IgG |
| HPAB-1102-FY | Mouse Anti-CXCL8 Recombinant Antibody (clone 197.2) | ELISA, IA, Block | Mouse IgG |
| HPAB-1103-FY | Mouse Anti-CXCL8 Recombinant Antibody (clone 81.1) | ELISA, IA, Block | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0059-YC-F(E) | Human Anti-CXCL8 Recombinant Antibody; Fab Fragment (HPAB-N0059-YC-F(E)) | FuncS | Human Fab |
| HPAB-1101-FY-S(P) | Mouse Anti-CXCL8 Recombinant Antibody (clone 656.35); Fab Fragment | ELISA, IA, Block | Mouse Fab |
| HPAB-1102-FY-S(P) | Mouse Anti-CXCL8 Recombinant Antibody (clone 197.2); Fab Fragment | ELISA, IA, Block | Mouse Fab |
| HPAB-1103-FY-S(P) | Mouse Anti-CXCL8 Recombinant Antibody (clone 81.1); Fab Fragment | ELISA, IA, Block | Mouse Fab |
| HPAB-1104-FY-S(P) | Mouse Anti-CXCL8 Recombinant Antibody; scFv Fragment (HPAB-1104-FY-S(P)) | ELISA | Mouse scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1101-FY-F(E) | Mouse Anti-CXCL8 Recombinant Antibody (clone 656.35); scFv Fragment | ELISA, IA, Block | Mouse scFv |
| HPAB-1102-FY-F(E) | Mouse Anti-CXCL8 Recombinant Antibody (clone 197.2); scFv Fragment | ELISA, IA, Block | Mouse scFv |
| HPAB-1103-FY-F(E) | Mouse Anti-CXCL8 Recombinant Antibody (clone 81.1); scFv Fragment | ELISA, IA, Block | Mouse scFv |
| HPAB-S0086-YC-S(P) | Human Anti-CXCL8 Recombinant Antibody (clone h6G4V11); scFv Fragment | ELISA, Inhib | Humanized scFv |
| HPAB-S0087-YC-S(P) | Human Anti-CXCL8 Recombinant Antibody (clone h6G4V11N35A); scFv Fragment | ELISA, Inhib, FuncS | Humanized scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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