Mouse Anti-CYCS Recombinant Antibody (VS3-FY2682)
CAT#: VS3-FY2682
The anti-CYCS antibody is a mouse recombinant monoclonal antibody that is designed to selectively bind to human Cytochrome C protein. It exhibits cross-reactivity with mouse, rat, chicken. This monoclonal antibody is potential for conducting research on disease research of Thrombocytopenia 4 and Autosomal Thrombocytopenia With Normal Platelets.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human heart muscle
Immunohistochemical staining of human heart muscle shows moderate cytoplasmic positivity in myocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18597/42408_B_6_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12177_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Bowman's capsule
Staining: High
Intensity: Strong
Quantity:>75%
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining: High
Intensity: Strong
Quantity:>75%
Proximal tubules (cell body)
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
Round or early spermatids
Staining: Medium
Intensity: Strong
Quantity: <25%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_6_6.jpg
Normal Tissue
Figure 8 Heart muscle
Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12177_B_5_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4222/12109_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172115-CYCS
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Cytochrome C, somatic of human, mouse, rat and chicken origins
- Species Reactivity
- Human, Mouse, Rat, Chicken
- Applications
- WB, IHC, ICC
- Conjugate
- Unconjugated, FITC
- Related Disease
- Thrombocytopenia 4 and Autosomal Thrombocytopenia With Normal Platelets
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunocytochemistry: 1/50-1/200
Target
- Alternative Names
- Cytochrome C, Somatic; CYC; Cytochrome C; THC4; HCS
- Gene ID
- 54205
- UniProt ID
- P99999
- Sequence Similarities
- Belongs to the cytochrome c family.
- Cellular Localization
- Mitochondrion intermembrane space
- Post Translation Modifications
- Binds 1 heme c group covalently per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
Ubiquitination at Lys40 and Lys80
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_061820.1
- Function
- Plays a role in apoptosis.
Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CYCS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-258-F(E) | Recombinant Anti-human CYCS Antibody Fab Fragment | FC, Neut, Funcs | Fab |
| FAMAB-0253JF-F(E) | Mouse Anti-CYCS Recombinant Antibody (clone 1G1.E9); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0254JF-F(E) | Mouse Anti-CYCS Recombinant Antibody (clone 7D4.H4); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0255JF-F(E) | Mouse Anti-CYCS Recombinant Antibody (clone 2F8.C10); Fab Fragment | ELISA, FuncS | Mouse Fab |
| FAMAB-0256JF-F(E) | Mouse Anti-CYCS Recombinant Antibody (clone 1F5.D1); Fab Fragment | ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0006MZ | Recombinant Chicken Anti-Cytochrome c IgY (1E4) | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-698CQ | Mouse Anti-CYCS Recombinant Antibody (clone 6H2.B4) | IP, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0895 | Hi-Affi™ Rabbit Anti-CYCS Recombinant Antibody (clone DS895AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0253JF | Mouse Anti-CYCS Recombinant Antibody (clone 1G1.E9) | ELISA, FuncS | Mouse IgG |
| FAMAB-0254JF | Mouse Anti-CYCS Recombinant Antibody (clone 7D4.H4) | ELISA, FuncS | Mouse IgG |
| FAMAB-0255JF | Mouse Anti-CYCS Recombinant Antibody (clone 2F8.C10) | ELISA, FuncS | Mouse IgG |
| FAMAB-0256JF | Mouse Anti-CYCS Recombinant Antibody (clone 1F5.D1) | ELISA, FuncS | Mouse IgG |
| FAMAB-0257JF | Mouse Anti-CYCS Recombinant Antibody (clone 6A7.E5) | ELISA, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0253JF-S(P) | Mouse Anti-CYCS Recombinant Antibody (clone 1G1.E9); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0254JF-S(P) | Mouse Anti-CYCS Recombinant Antibody (clone 7D4.H4); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0255JF-S(P) | Mouse Anti-CYCS Recombinant Antibody (clone 2F8.C10); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0256JF-S(P) | Mouse Anti-CYCS Recombinant Antibody (clone 1F5.D1); scFv Fragment | ELISA, FuncS | Mouse scFv |
| FAMAB-0257JF-S(P) | Mouse Anti-CYCS Recombinant Antibody (clone 6A7.E5); scFv Fragment | ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY75 | AbPlus™ Anti-CYCS Magnetic Beads (CBACN-171) | IP, Protein Purification | |
| VS-0724-YC322 | AbPlus™ Anti-CYCS Magnetic Beads (VS-0724-YC322) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY601 | Anti-CYCS Immunohistochemistry Kit | IHC | |
| VS-0525-XY1839 | Anti-Mouse CYCS Immunohistochemistry Kit | IHC | |
| VS-0525-XY1838 | Anti-Human CYCS Immunohistochemistry Kit | IHC | |
| VS-0525-XY1840 | Anti-Canine CYCS Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC40 | Recombinant Anti-CYCS (AA 44-47 x AA 60-62) Biparatopic Antibody, Tandem scFv (Clone 1G1.E9 x Clone 1F5.D1) | ELISA | Tandem scFv |
| VS-0525-YC42 | Recombinant Anti-CYCS (AA 44-47 x AA 60-62) Biparatopic Antibody, Tandem scFv (Clone 2F8.C10 x Clone 6A7.E5) | ELISA | Tandem scFv |
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