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    Rabbit Anti-DNMT3A Recombinant Antibody (VS13-YC316) (CAT#: VS13-YC316)

    The Rabbit Anti-DNMT3A Recombinant Antibody is specific for human and mouse DNMT3A. DNMT3A, involved in de novo methylation, impacts X-chromosome inactivation and development, with key roles in imprinting and cellular epigenetic transitions. The anti-DNMT3A antibody can be used for Western blot (1/1000-1/5000), Immunocytochemistry (1/50-1/200), Immunofluorescence (1/50-1/200).

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    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/607_H4_2_selected.jpg
    Figure 2 IHC staining of human kidney
    Figure 2 IHC staining of human kidney
    (Immunohistochemical staining of human kidney shows strong nuclear positivity in cells in tubules and cells in glomeruli.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_8_5_selected.jpg
    Figure 3 IHC staining of human placenta
    Figure 3 IHC staining of human placenta
    (Immunohistochemical staining of human placenta shows strong nuclear positivity in trophoblastic cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9469/ihc_selected.jpg
    Figure 4 IF staining of human cell line A-431
    Figure 4 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/609_H4_1_red_green.jpg
    Figure 5 IF staining of human cell line U-251 MG
    Figure 5 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/604_H4_1_red_green.jpg
    Normal Tissue
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Glial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Neuronal cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_B_8_5.jpg
    Figure 7 Colon
    Figure 7 Colon
    (Endothelial cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Glandular cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Peripheral nerve/ganglion
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_8_3.jpg
    Figure 8 Liver
    Figure 8 Liver
    (Hepatocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_8_4.jpg
    Figure 9 Kidney
    Figure 9 Kidney
    (Cells in glomeruli
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Cells in tubules
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_7_5.jpg
    Figure 10 Testis
    Figure 10 Testis
    (Cells in seminiferous ducts
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Leydig cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_6_6.jpg
    Figure 11 Lymph node
    Figure 11 Lymph node
    (Germinal center cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Non-germinal center cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/26588/55045_A_9_8.jpg
    RNA Expression
    Figure 12 RNA cell line category: Cell line enhanced (NTERA-2, REH, SH-SY5Y)
    Figure 12 RNA cell line category: Cell line enhanced (NTERA-2, REH, SH-SY5Y)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119772-DNMT3A

    Specifications

    • Immunogen
    • Recombinant human Dnmt3a, aa 600-640.
    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human and Mouse DNMT3A
    • Species Reactivity
    • Human, Mouse
    • Applications
    • WB, ICC, IF
    • Conjugate
    • NONE
    • Related Disease
    • Tatton-Brown-Rahman Syndrome; Heyn-Sproul-Jackson Syndrome

    Product Property

    • Clonality
    • Monoclonal
    • Purification
    • Protein A purified
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
    • Preservative
    • 0.05% Sodium azide
    • Storage
    • Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Shipping with ice pack.

    Applications

    • Application Notes
    • Western blot (WB): 1/1000-1/5000
      Immunocytochemistry (ICC): 1/50-1/200
      Immunofluorescence (IF): 1/50-1/200

    Target

    • Alternative Names
    • DNA Methyltransferase 3 Alpha; DNA (Cytosine-5-)-Methyltransferase 3 Alpha; DNA MTase HsaIIIA; EC 2.1.1.37; M.HsaIIIA; DNA (Cytosine-5)-Methyltransferase 3A;
    • Long Name
    • DNA Methyltransferase 3 Alpha
    • Cellular Localization
    • Nucleus; Chromosome; Cytoplasm
    • Function
    • It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    DrMAB-311 Human Anti-DNMT3A Recombinant Antibody (clone D422) ELISA, IP-MS Human IgG
    VS3-WK86 Mouse Anti-DNMT3A Recombinant Antibody (clone F5-G11) WB, ELISA Mouse IgG2a
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    VS3-XY3335 Rabbit Anti-DNMT3A Recombinant Antibody (clone R02-3C2) WB, IHC-P, ICC, IF, FC Rabbit IgG
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