AibGenesis™ Rabbit Anti-DOT1L Recombinant Antibody (AibG-Rb-OT125)
CAT#: VS14-YC325
This AI-modeled anti-DOT1L mAb (AibG-Rb-OT125) is engineered for exceptional binding affinity, validated for DOT1L recognition in human, mouse, and rat. DOT1L is the sole histone methyltransferase responsible for the methylation of Histone H3 at Lys79 (H3K79). It is a major epigenetic regulator of gene transcription and DNA repair, and is frequently hijacked in MLL-rearranged leukemias.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11875/1201_C5_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71217/1400_C9_1_selected.jpg
Normal Tissue
Figure 3 IHC staining of human testis
Immunohistochemical staining of human testis shows moderate positivity in subset of cells in seminiferous ducts.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74977/166292_A_6_6_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74977/166292_B_9_5.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74977/166292_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104885-DOT1L
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- DOT1L
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-OT125
- Applications
- Western Blot (WB)
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Concentration
- 0.3 mg/mL
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 40% Glycerol and 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (WB): 1/1000
Target
- Alternative Names
- DOT1 Like Histone Lysine Methyltransferase; Histone H3-K79 Methyltransferase; Histone Methyltransferase DOT1L; Lysine N-Methyltransferase 4; DOT1-Like Protein; H3-K79-HMTase; KMT4; Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific;
- Gene ID
- 84444
- UniProt ID
- Q8TEK3
- Long Name
- DOT1 Like Histone Lysine Methyltransferase
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "DOT1L"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1042CT | Recombinant Mouse anti-Human DOT1L Monoclonal antibody (EML1954) | FC, IP, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1037 | Hi-Affi™ Rabbit Anti-DOT1L Recombinant Antibody (clone DS1037AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0639J | Rabbit Anti-DOT1L Recombinant Antibody (clone 3B6) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY461 | Recombinant Rabbit Anti-DOT1L Antibody (clone R01-7F6) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2057 | Anti-DOT1L Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-FY1452 | Human Anti-DOT1L Recombinant Antibody (clone 2506W1347) | ELISA, IP MS | Human IgG1 |
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