Mouse Anti-DPP4 Recombinant Antibody (VS3-CJ62)
CAT#: VS3-CJ62
This product is a mouse antibody that recognizes DPP4.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68778/169922_A_9_2_selected.jpg
Normal Tissue
Figure 2 Parathyroid gland
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_A_3_8_selected.jpg
Normal Tissue
Figure 3 Prostate
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45970/113236_A_2_5_val_selected.jpg
Normal Tissue
Figure 4 Salivary gland
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_B_2_1.jpg
Normal Tissue
Figure 5 Colon
Enterocytes - Microvilli Staining: Medium Intensity: Moderate Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_A_8_4.jpg
Normal Tissue
Figure 7 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity: 75%-25% Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, RPTEC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197635-DPP4
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Specifications
- Immunogen
- Recombinant fragment of rat DPP4 (C-terminus)
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Rat DPP4
- Species Reactivity
- Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- 1 mg/mL (lot specific)
- Buffer
- 50% Glycerol, 1% BSA, PBS, pH7.4.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in ELISA (1:5000-1:20000), Western Blot (1:100-1:2000).
Target
- Alternative Names
- CD26; DPPIV
- Gene ID
- 25253
- UniProt ID
- P27487
- Sequence Similarities
- Belongs to the peptidase S9B family. DPPIV subfamily.
- Cellular Localization
- Plasma membrane
- Post Translation Modifications
- The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
N- and O-Glycosylated.
Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.
- Protein Refseq
- NP_001926.2
- Function
- Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217).
Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230).
Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217).
Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392).
In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948).
May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048).
When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790).
Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924).
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948).
(Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-316 | Mouse Anti-Dpp4 Recombinant Antibody (clone 11A19) | ELISA, WB, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
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| PSBL-316 | Mouse Anti-Dpp4 Recombinant Antibody (clone 11A19); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
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| PFBL-316 | Mouse Anti-Dpp4 Recombinant Antibody (clone 11A19); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
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| PABL-690 | Mouse Anti-Dpp4 Recombinant Antibody (clone MK-0431) | WB, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
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| PFBL-683 | Mouse Anti-DPP4 Recombinant Antibody (clone MK-0431); Fab Fragment | WB, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
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| PSBL-683 | Mouse Anti-Dpp4 Recombinant Antibody (clone MK-0431); scFv Fragment | WB, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2126MZ | Recombinant Mouse Anti-Human DPP4 Antibody (clone 245-3D3), PE-Conjugated | FC, FuncS, IHC-Fr, IP | Mouse antibody |
| CAT | Product Name | Application | Type |
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| MOR-1041 | Hi-Affi™ Rabbit Anti-DPP4 Recombinant Antibody (clone DS1041AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| HPAB-0213-YC | Mouse Anti-DPP4 Recombinant Antibody (HPAB-0213-YC) | FC, FuncS | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0214-YC | Human Anti-DPP4 Recombinant Antibody (HPAB-0214-YC) | ELISA, Inhib | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0213-YC-S(P) | Mouse Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0213-YC-S(P)) | FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0214-YC-S(P) | Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0214-YC-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-YC-S(P) | Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0215-YC-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0213-YC-F(E) | Mouse Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-0213-YC-F(E)) | FC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0214-YC-F(E) | Human Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-0214-YC-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-YC-F(E) | Human Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-0215-YC-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY98 | CytoStream™ Rat Anti-DPP4 Recombinant Antibody (clone H194-112) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY99 | CytoStream™ Mouse Anti-DPP4 Recombinant Antibody (VS-0225-XY99) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY100 | CytoStream™ Mouse Anti-DPP4 Recombinant Antibody (VS-0225-XY100) | FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY101 | Human Anti-DPP4 scFv-Fc Chimera (VS-0425-FY101) | WB, DB, ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2067 | Anti-DPP4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2068 | Anti-Mouse DPP4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2069 | Anti-Rat DPP4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC92 | Recombinant Anti-DPP4 Eliminating Antibody, pH-Sensitive (OX61 var.) | Antigen-Sweeping In Vivo. | Mouse IgG2a |
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