Anti-EGFL7 Antibody Prodrug, Protease Activated (VS-1025-YC198)
CAT#: VS-1025-YC198
The Anti-EGFL7 Antibody Prodrug, Protease Activated (VS-1025-YC198) is an antibody prodrug comprised of a recombinant mouse antibody targeting human EGFL7, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to EGFL7 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to EGFL7 effectively. EGFL7 is a secreted factor that is highly expressed by endothelial cells in the tumor microenvironment and acts as a key regulator of angiogenesis. It promotes the proliferation and migration of endothelial cells, thus supporting the vascularization and growth of the tumor.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/50716/118119_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (EFO-21, HUVEC TERT2, RPMI-8226, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000172889-EGFL7
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human EGFL7
- Target
- EGFL7
- Species Reactivity
- Human, Mouse
- Isotype
- IgG2b
- Epitope
- CCP
- Affinity Constant
- KD = 0.756 nM (mEGFL7), KD = 0.473 nM (hEGFL7)
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants
- Alternative Names
- NEU1; ZNEU1; VE-STATIN
- Gene ID
- 51162
- UniProt ID
- Q9UHF1
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Datasheet
MSDS
COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| TAB-902 | Anti-Human EGFL7 Recombinant Antibody (TAB-902) | Block | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2365MZ | Recombinant Mouse Anti-Human EGFL7 Antibody | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0001-DJB | Mouse Anti-EGFL7 Recombinant Antibody (HPAB-0001-DJB) | ELISA, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-DJB | Mouse Anti-EGFL7 Recombinant Antibody (HPAB-0002-DJB) | ELISA, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0003-DJB | Mouse Anti-EGFL7 Recombinant Antibody (HPAB-0003-DJB) | ELISA, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0001-DJB-S(P) | Mouse Anti-EGFL7 Recombinant Antibody scFv Fragment (HPAB-0001-DJB-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-DJB-S(P) | Mouse Anti-EGFL7 Recombinant Antibody scFv Fragment (HPAB-0002-DJB-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0003-DJB-S(P) | Mouse Anti-EGFL7 Recombinant Antibody; scFv Fragment (HPAB-0003-DJB-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0001-DJB-F(E) | Mouse Anti-EGFL7 Recombinant Antibody Fab Fragment (HPAB-0001-DJB-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0002-DJB-F(E) | Mouse Anti-EGFL7 Recombinant Antibody Fab Fragment (HPAB-0002-DJB-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0003-DJB-F(E) | Mouse Anti-EGFL7 Recombinant Antibody; Fab Fragment (HPAB-0003-DJB-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-902 | Afuco™ Anti-EGFL7 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-902) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0951WJ | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v1) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0951WJ-S(P) | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v1); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0952WJ-S(P) | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v17); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0951WJ-F(E) | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v1); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0952WJ-F(E) | Mouse Anti-EGFL7 Recombinant Antibody (clone 4F11.v17); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY102 | Mouse Anti-EGFL7 (clone 18F7.v6) scFv-Fc Chimera | Inhib | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC63 | Recombinant Anti-EGFL7 (AA 66-69 x AA 88-90) Biparatopic Antibody, Tandem scFv | ELISA, WB | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC98 | Recombinant Anti-EGFL7 Eliminating Antibody, pH-Sensitive (VS-0625-YC98) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC109 | SmartAb™ Recombinant Anti-EGFL7 pH-dependent Antibody (VS-0825-YC109) | ELISA, WB | Mouse IgG2b |
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