Rabbit Anti-ERBB4 Recombinant Antibody (VS13-YC364) (CAT#: VS13-YC364)

• Immunogen
• Recombinant human ErbB4, aa 721-972.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat ERBB4

• Species Reactivity
• Human, Rat

• Applications
• WB

• Conjugate
• NONE

• Related Disease
• Cancer

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.

• Preservative
• 0.01% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500-1/1000

• Alternative Names
• Erb-B2 Receptor Tyrosine Kinase 4; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 4; Tyrosine Kinase-Type Cell Surface Receptor HER4; Human Epidermal Growth Factor Receptor 4; Proto-Oncogene-Like Protein C-ErbB-4; EC 2.7.10.1; P180erbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4;

• Gene ID
• 2066

• UniProt ID
• Q15303

• Long Name
• Erb-B2 Receptor Tyrosine Kinase 4

• Cellular Localization
• Cell membrane

• Protein Refseq
• XP_005246433.1; XP_005246434.1

• Function
• Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF.
  Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors.
  Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses.
  Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Select a product category from the dropdown menu below to view related products.