Rabbit Anti-ERBB4 Recombinant Antibody (VS13-YC364)
CAT#: VS13-YC364
The Rabbit Anti-ERBB4 Recombinant Antibody is specific for human and rat ERBB4. ERBB4, another RTK family member, is activated by ligand binding to influence cellular outcomes like mitogenesis, with mutations impacting cancer development and signaling variabilities. The anti-ERBB4 antibody can be used for Western blot (1/500-1/1000).
Gene Expression
Normal Tissue
Figure 1 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_5.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_8_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, EFO-21, HEK93, RPTEC TERT1, SCLC-21H, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000178568-ERBB4
❮
❯
Specifications
- Immunogen
- Recombinant human ErbB4, aa 721-972.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat ERBB4
- Species Reactivity
- Human, Rat
- Applications
- WB
- Conjugate
- NONE
- Related Disease
- Cancer
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Target
- Alternative Names
- Erb-B2 Receptor Tyrosine Kinase 4; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 4; Tyrosine Kinase-Type Cell Surface Receptor HER4; Human Epidermal Growth Factor Receptor 4; Proto-Oncogene-Like Protein C-ErbB-4; EC 2.7.10.1; P180erbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4;
- Gene ID
- 2066
- UniProt ID
- Q15303
- Long Name
- Erb-B2 Receptor Tyrosine Kinase 4
- Cellular Localization
- Cell membrane
- Protein Refseq
- XP_005246433.1; XP_005246434.1
- Function
- Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF.
Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors.
Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses.
Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS13-YC364. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "ERBB4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-470 | Mouse Anti-ERBB4 Recombinant Antibody (PABL-470) | WB, IF, FuncS | Mouse IgG |
| HPAB-0530YY | Human Anti-ERBB4 Recombinant Antibody (HPAB-0530YY) | ELISA | Human IgG1 |
| HPAB-0531YY | Human Anti-ERBB4 Recombinant Antibody (HPAB-0531YY) | ELISA | Human IgG1 |
| HPAB-0532YY | Human Anti-ERBB4 Recombinant Antibody (HPAB-0532YY) | ELISA | Human IgG1 |
| VS3-WK2025 | Rabbit Anti-ERBB4 (pY1162) Recombinant Antibody (clone R07-4C0) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-467 | Mouse Anti-ERBB4 Recombinant Antibody; Fab Fragment (PFBL-467) | WB, IF, FuncS | Mouse Fab |
| HPAB-0530YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0530YY-F(E)) | ELISA | Human Fab |
| HPAB-0531YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0531YY-F(E)) | ELISA | Human Fab |
| HPAB-0532YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0532YY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-467 | Mouse Anti-ERBB4 Recombinant Antibody; scFv Fragment (PSBL-467) | WB, IF, FuncS | Mouse scFv |
| HPAB-0530YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0530YY-S(P)) | ELISA | Human scFv |
| HPAB-0531YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0531YY-S(P)) | ELISA | Human scFv |
| HPAB-0532YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0532YY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-073CT | Anti-Human HER4 Recombinant Antibody (HE4B-33) | ELISA, Inhibition | Human antibody |
| TAB-073CT-S(P) | Anti-Human HER4 Recombinant Antibody scFv Fragment (HE4B-33) | ELISA, Inhibition | Human antibody |
| TAB-073CT-F(E) | Anti-Human HER4 Recombinant Antibody Fab Fragment (HE4B-33) | ELISA, Inhibition | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-074CT | Mouse Anti-ERBB4 Recombinant Antibody (TAB-074CT) | ELISA, Inhibion, WB | Mouse IgG |
| TAB-074CT-S(P) | Mouse Anti-ERBB4 Recombinant Antibody; scFv Fragment (TAB-074CT-S(P)) | ELISA, Inhibion, WB | Mouse scFv |
| TAB-074CT-F(E) | Mouse Anti-ERBB4 Recombinant Antibody; Fab Fragment (TAB-074CT-F(E)) | ELISA, Inhibion, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-743CQ | Mouse Anti-ERBB4 Recombinant Antibody (clone CBL391) | Block | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-744CQ | Mouse Anti-ERBB4 Recombinant Antibody (clone CBL930) | IP, Neut, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1180 | Hi-Affi™ Rabbit Anti-ERBB4 Recombinant Antibody (clone DS1180AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF427 | A*02:01/Human ERBB-4 (VLVKSPNHV) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC301 | Recombinant Anti-ERBB4 Vesicular Antibody, EV Displayed (VS-0425-YC301) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2339 | Anti-ERBB4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2340 | Anti-Mouse ERBB4 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: SPR, Inhib, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, Neut
-2.png)
Application: ELISA
Application: IF, ICC, WB, IHC-P, IP
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
