Mouse Anti-F2 Recombinant Antibody (VS-0524-YC44) (CAT#: VS-0524-YC44)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human prothrombin

• Species Reactivity
• Human

• Purification
• Protein G purified

• Purity
• >95%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservative

• Storage
• Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western blot: 2 μg/mL

• Alternative Names
• Coagulation Factor II, Thrombin; Prepro-Coagulation Factor II; EC 3.4.21.5; Coagulation Factor II (Thrombin); Coagulation Factor II; Prothrombin B-Chain; Serine Protease

• Gene ID
• 14061

• UniProt ID
• P19221

• Long Name
• prothrombin

• Sequence Similarities
• Belongs to the peptidase S1 family.

• Post Translation Modifications
• The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.

• Protein Refseq
• NP_034298.1

• Function
• Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).

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