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F2
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- Recombinant Anti-human F2 Antibody (MOB-344)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, Dot, FuncS
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- Recombinant Human Anti-human F2 Antibody (MHH-344)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: Neut, IF, FuncS
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- Mouse Anti-F2 Recombinant Antibody (clone 513) (NEUT-760CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, Inhib, WB
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- Mouse Anti-F2 Recombinant Antibody (NEUT-761CQ) (NEUT-761CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, Inhib
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- Human Anti-F2 Recombinant Antibody (clone h1601-008) (HPAB-0049-YC)
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- Derivation: Humanized
- Species Reactivity: Human, Monkey
- Type: Humanized IgG4, κ
- Application: ELISA
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- Human Anti-F2 Antibody (clone YC049), mRNA (PABL-092-mRNA)
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- Species Reactivity: Human
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- Human Anti-F2 Antibody (clone h1601-008), mRNA (HPAB-0049-YC-mRNA)
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- Species Reactivity: Human, Monkey
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- Human Anti-F2 Antibody (clone YC050), mRNA (PABL-469-mRNA)
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- Species Reactivity: Human
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- Rabbit Anti-F2 Recombinant Antibody (clone R08-5G1) (VS3-FY1856)
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- Species Reactivity: Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
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- Mouse Anti-F2 Recombinant Antibody (VS-0524-YC44) (VS-0524-YC44)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB, SPR
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- Mouse Anti-F2 Recombinant Antibody (clone aTM-1) (HPAB-0050-YC)
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- Derivation: Phage display library
- Species Reactivity: Human, Monkey
- Type: Mouse IgG
- Application: ELISA
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- Human Anti-F2 Recombinant Antibody (clone AP021/YC) (HPAB-J0085-YC)
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- Species Reactivity: Human
- Type: Human IgA
- Application: FuncS
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- Human Anti-F2 Recombinant Antibody (clone G) (HPAB-J0086-YC)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS
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- Human Anti-F2 Recombinant Antibody (clone G S30A) (HPAB-J0087-YC)
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- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS
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- Mouse Anti-F2 Recombinant Antibody (clone aTM-1); Fab Fragment (HPAB-0050-YC-F(E))
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- Derivation: Phage display library
- Species Reactivity: Human, Monkey
- Type: Mouse Fab
- Application: ELISA
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- Human Anti-F2 Recombinant Antibody (clone h1601-008); Fab Fragment (HPAB-0049-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human, Monkey
- Type: Humanized Fab
- Application: ELISA
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- Human Anti-F2 Recombinant Antibody (clone h1601-008); scFv Fragment (HPAB-0049-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human, Monkey
- Type: Humanized scFv
- Application: ELISA
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- Mouse Anti-F2 Recombinant Antibody (clone aTM-1); scFv Fragment (HPAB-0050-YC-S(P))
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- Derivation: Phage display library
- Species Reactivity: Human, Monkey
- Type: Mouse scFv
- Application: ELISA
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- Human Anti-F2 Recombinant Antibody (clone AP021/YC); scFv Fragment (HPAB-J0085-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
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- Human Anti-F2 Recombinant Antibody (clone G); scFv Fragment (HPAB-J0086-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
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- Human Anti-F2 Recombinant Antibody (clone YC046); scFv Fragment (HPAB-J0087-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
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- Human Anti-F2 Recombinant Antibody (clone AP021/YC); Fab Fragment (HPAB-J0085-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS
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- Human Anti-F2 Recombinant Antibody (clone G); Fab Fragment (HPAB-J0086-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS
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- Human Anti-F2 Recombinant Antibody (clone G S30A); Fab Fragment (HPAB-J0087-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FuncS
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- Derivation: Non- immunized llama phage-display library
- Species Reactivity: Human
- Type: Single domain antibody
- Application: ELISA
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- Derivation: Non- immunized llama phage-display library
- Species Reactivity: Human
- Type: Single domain antibody
- Application: ELISA
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- Recombinant Human Anti-human F2 Antibody Fab Fragment (MHH-344-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, WB, Dot, FuncS
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- Recombinant Human Anti-human F2 Antibody scFv Fragment (MHH-344-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, WB, FuncS
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- LDTI scaffold protein anti-Human Thrombin (SLD-L120)
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- Scaffold Name: LDTI
- Target: Thrombin
- Species Reactivity: Human
- Derivation: Phage display
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- Recombinant Anti-human F2 Antibody Fab Fragment (MOB-344-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, IP, FuncS
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- Recombinant Anti-human F2 Antibody scFv Fragment (MOB-344-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, ELISA, FuncS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IP, RIA, WB
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- Derivation: Humanized
- Species Reactivity: Human, Monkey
- Type: Human IgG4 kappa
- Application: Antigen-Sweeping In Vivo.
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- Anti-F2 Immunohistochemistry Kit (VS-0525-XY2407)
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- Species Reactivity: Human
- Target: F2
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (Hep G2)
Interaction
Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5. In plasma, interacts (via N-terminus) with alpha-1-microglobulin with molar ratio 1:2 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin.
Molecular function
Hydrolase, Protease, Serine protease
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