Rabbit Anti-FMR1 Recombinant Antibody (VS13-YC407) (CAT#: VS13-YC407)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat FMR1

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, ICC, IF, IHC-P

• Conjugate
• NONE

• Related Disease
• Fragile X Syndrome and Premature Ovarian Failure

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/1000-1/5000
  Immunofluorescence (IF-cell): 1/100-1/500
  Immunofluorescence (IF-tissue): 1/100-1/500
  Immunohistochemistry-paraffin (IHC-P): 1/50-1/1000

• Alternative Names
• Fragile X Mental Retardation 1; Fragile X Mental Retardation Protein 1; FMRP; Synaptic Functional Regulator FMR1; Premature Ovarian Failure 1; Protein FMR-1; FRAXA; POF1; POF;

• Gene ID
• 2332

• UniProt ID
• Q06787

• Long Name
• Fragile X Mental Retardation 1

• Sequence Similarities
• Belongs to the FMR1 family.

• Cellular Localization
• Cell membrane; Cell projection; Centromere; Chromosome; Cytoplasm

• Protein Refseq
• NP_001172004.1; NP_001172005.1; NP_001172010.1; NP_001172011.1; NP_002015.1

• Function
• Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors.
  Plays a role in the alternative splicing of its own mRNA.
  Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity).
  Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity).

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Select a product category from the dropdown menu below to view related products.