AibGenesis™ Rabbit Anti-FOXL2 Recombinant Antibody (AibG-Rb-FO425)
CAT#: VS-0426-FY425
Established via our AI-powered antibody discovery platform, this Rabbit IgG targets FOXL2. Validated for WB, IHC, and IP across multiple species, it provides high specificity for studying ovarian development, granulosa cell function, and mutations linked to Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm & midbody ring.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69613/1339_C5_3_selected.jpg
Normal Tissue
Figure 2 High expression in ovary
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69613/155970_A_6_7_val_selected.jpg
Normal Tissue
Figure 3 Low expression in testis
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69613/155970_A_5_6_val_selected.jpg
Normal Tissue
Figure 4 Ovary
Follicle cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Ovarian stroma cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69613/155970_A_6_7.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HEL, hTCEpi, K-562, SiHa, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000183770-FOXL2
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human FOXL2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-FO425
- Applications
- Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Diseases associated with FOXL2 include Blepharophimosis, Ptosis, And Epicanthus Inversus and Premature Ovarian Failure 3
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% Glycerol, 0.05% Protective protein
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:500-1:2000), Immunohistochemistry (1:200-1:2000), Immunocytochemistry/Immunofluorescence (1:20-1:50), Immunoprecipitation (1:20-1:50)
Target
- Alternative Names
- BPES; PFRK; POF3; BPES1; PINTO
- Gene ID
- 668
- UniProt ID
- P58012
- Long Name
- Forkhead Box L2
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity. (P58012-FOXL2_HUMAN)
Modification sites at PhosphoSitePlus (P58012)
Modification sites at neXtProt
- Protein Refseq
- NP_075555.1
- Function
- Activates SIRT1 transcription under cellular stress conditions.
Activates transcription of OSR2.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "FOXL2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1065MZ | Recombinant Mouse Anti-Human FOXL2 Antibody (clone 373D2b) | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC417 | Rabbit Anti-Foxl2 Recombinant Antibody (VS13-YC417) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2627 | Anti-FOXL2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2628 | Anti-Mouse FOXL2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC356 | AibGenesis™ Rabbit Anti-FOXL2 Recombinant Antibody (AibG-Rb-XL156) | WB | Rabbit IgG |
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