Rabbit Anti-GCG Recombinant Antibody (clone R04-8D3) (CAT#: VS3-XY3366)
The antibody is a recombinant rabbit antibody targeting the GCG (Glucagon), which regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. It specifically reacts with human GCG. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/1675_C6_32_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/1675_C6_32_selected.jpg
Figure 2 High expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/123313_A_2_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/123313_A_2_3_val_selected.jpg
Figure 3 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/123313_A_9_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/123313_A_9_4_val_selected.jpg
Figure 4 Pancreas
(Pancreatic endocrine cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40/255_A_2_3.jpg
(Pancreatic endocrine cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40/255_A_2_3.jpg
Figure 5 RNA cell line category: Cell line enhanced (EFO-21, U-2 OS, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115263-GCG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115263-GCG
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human GCG
- Species Reactivity
- Human
- Clone
- R04-8D3
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Dumping Syndrome; Hyperglycemia
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- GLP1; GLP2; GRPP; GLP-1
- Gene ID
- 2641
- UniProt ID
- P01275
- Long Name
- Glucagon
- Cellular Localization
- Secreted
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P01275)
Modification sites at neXtProt (NX_P01275)
- Protein Refseq
- NP_002045.1
- Function
- [Glucagon]: Plays a key role in glucose metabolism and homeostasis.
Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia.
Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Agonistic Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0117MZ | Recombinant Mouse Anti-Glucagon-Like Peptide (GLP1) Antibody (clone JD/GLP-3/20) | ICC, IHC-P | Mouse antibody |
| ZG-0076C | Mouse Anti-GCG Recombinant Antibody (clone ABT-GCG) | IHC-P, IF | Mouse IgG |
| ZG-0077C | Mouse Anti-GCG Recombinant Antibody (clone PT1696) | IHC-P, IF | Mouse IgG |
| ZG-0683J | Rabbit Anti-GCG Recombinant Antibody (clone 1D10) | ELISA | Rabbit IgG |
| VS4-WK194 | Mouse Anti-GCG Recombinant Antibody (VS4-WK194) | ELISA, IHC | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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