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GCG

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
Predicted location

Secreted

Single cell type specificity

Cell type enriched (Enteroendocrine cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (EFO-21, U-2 OS, U-698)

Molecular function

Hormone

More Types Infomation

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