Mouse Anti-GCG Recombinant Antibody (VS3-CJ252)
CAT#: VS3-CJ252
This product is a mouse antibody that recognizes GCG.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/1675_C6_32_selected.jpg
Normal Tissue
Figure 2 High expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/123313_A_2_3_val_selected.jpg
Normal Tissue
Figure 3 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36760/123313_A_9_4_val_selected.jpg
Normal Tissue
Figure 4 Pancreas
Pancreatic endocrine cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40/255_A_2_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (EFO-21, U-2 OS, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115263-GCG
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Specifications
- Immunogen
- KLH-conjugated synthetic peptide encompassing a sequence within human Glucagon
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human GCG
- Species Reactivity
- Human
- Applications
- IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Immunogen affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.2% BSA, PBS.
- Preservative
- 0.01% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry (1:100-1:300).
Target
- Alternative Names
- GLP1; GLP2; GRPP; GLP-1; Glucagon
- Gene ID
- 2641
- UniProt ID
- P01275
- Sequence Similarities
- Belongs to the glucagon family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
- Protein Refseq
- NP_002045.1
- Function
- Glucagon: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.
Glucagon-like peptide 1: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645).
Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable).
Glucagon-like peptide 2: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.
Oxyntomodulin: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.
Glicentin: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "GCG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1415 | Hi-Affi™ Rabbit Anti-GCG Recombinant Antibody (clone DS1415AB) | WB | Rabbit IgG |
| MOR-4579 | Hi-Affi™ Rabbit Anti-GCG Recombinant Antibody (clone TH91DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0352-CN | Human Anti-GCG Recombinant Antibody (HPAB-0352-CN) | ELISA, FC, RIA | Human IgG4 |
| HPAB-0353-CN | Human Anti-GCG Recombinant Antibody (HPAB-0353-CN) | ELISA, FC, RIA | Human IgG4 |
| HPAB-0354-CN | Human Anti-GCG Recombinant Antibody (HPAB-0354-CN) | ELISA, FC, RIA | Human IgG1 |
| VS3-XY3366 | Rabbit Anti-GCG Recombinant Antibody (clone R04-8D3) | WB, IHC-P, ICC, IF | Rabbit IgG |
| VS7-HM999 | Mouse Anti-GCG Recombinant Antibody (clone CBL317HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0352-CN-S(P) | Human Anti-GCG Recombinant Antibody (HPAB-0352-CN-S(P)); scFv Fragment | ELISA, FC, RIA | Human scFv |
| HPAB-0353-CN-S(P) | Human Anti-GCG Recombinant Antibody (HPAB-0353-CN-S(P)); scFv Fragment | ELISA, FC, RIA | Human scFv |
| HPAB-0354-CN-S(P) | Human Anti-GCG Recombinant Antibody (HPAB-0354-CN-S(P)); scFv Fragment | ELISA, FC, RIA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0352-CN-F(E) | Human Anti-GCG Recombinant Antibody (HPAB-0352-CN-F(E)); Fab Fragment | ELISA, FC, RIA | Human Fab |
| HPAB-0353-CN-F(E) | Human Anti-GCG Recombinant Antibody (HPAB-0353-CN-F(E)); Fab Fragment | ELISA, FC, RIA | Human Fab |
| HPAB-0354-CN-F(E) | Human Anti-GCG Recombinant Antibody (HPAB-0354-CN-F(E)); Fab Fragment | ELISA, FC, RIA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-032CN | Human Anti-GCG Recombinant Antibody (NS-032CN) | ELISA | Human IgG2 |
| NS-032CN-F(E) | Human Anti-GCG Recombinant Antibody; Fab Fragment (NS-032CN-F(E)) | ELISA | Human Fab |
| NS-032CN-S(P) | Human Anti-GCG Recombinant Antibody; scFv Fragment (NS-032CN-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0662-CN | Mouse Anti-GCG Recombinant Antibody (clone 5F1) | WB, IHC, IF, FC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY27 | Mouse Anti-GCG Agonistic Antibody (VS-0724-XY27) | WB, Agonistic assays | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2760 | Anti-GCG Immunohistochemistry Kit | IHC | |
| VS-0525-XY2761 | Anti-Mouse GCG Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC128 | Recombinant Anti-GCG Eliminating Antibody, pH-Sensitive (VS-0625-YC128) | Antigen-Sweeping In Vivo. | Human IgG4 |
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