Rabbit Anti-GCSAM Recombinant Antibody (clone R03-7X6)
CAT#: VS3-XY3367
It is a recombinant rabbit antibody targeting the human GCSAM (Germinal center associated signaling and motility), which mediates the migration-inhibitory effects of IL6 and serves as a positive regulator of the RhoA signaling pathway. It has been determined using Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human GCSAM
- Species Reactivity
- Human
- Clone
- R03-7X6
- Applications
- IHC-P, ICC, IF, FC
- Related Disease
- Lymphoma; Diffuse Large B-Cell Lymphoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- HGAL; GCAT2; GCET2
- Gene ID
- 257144
- UniProt ID
- Q8N6F7
- Long Name
- Germinal center associated signaling and motility
- Cellular Localization
- Cytoplasm, Cell membrane
- Post Translation Modifications
- Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. (Q8N6F7-GCSAM_HUMAN)
Modification sites at PhosphoSitePlus (Q8N6F7)
Modification sites at neXtProt (NX_Q8N6F7)
- Protein Refseq
- XP_011510929.1; XP_011510931.1
- Function
- Involved in the negative regulation of lymphocyte motility.
It mediates the migration-inhibitory effects of IL6.
Serves as a positive regulator of the RhoA signaling pathway.
Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK.
Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
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- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GCSAM"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1725 | Rabbit Anti-GCSAM Recombinant Antibody (clone R05-4H2) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
| VS13-YC440 | Rabbit Anti-GCSAM Recombinant Antibody (VS13-YC440) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2770 | Anti-GCSAM Immunohistochemistry Kit | IHC |
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