Rabbit Anti-GCSAM Recombinant Antibody (clone R03-7X6) (CAT#: VS3-XY3367)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human GCSAM

• Species Reactivity
• Human

• Clone
• R03-7X6

• Applications
• IHC-P, ICC, IF, FC

• Related Disease
• Lymphoma; Diffuse Large B-Cell Lymphoma

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• IHC: 1/50-1/100
  IF: 1/50-1/200
  FC: 1/50-1/100

• Alternative Names
• HGAL; GCAT2; GCET2

• Gene ID
• 257144

• UniProt ID
• Q8N6F7

• Long Name
• Germinal center associated signaling and motility

• Cellular Localization
• Cytoplasm, Cell membrane

• Post Translation Modifications
• Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. (Q8N6F7-GCSAM_HUMAN)
  Modification sites at PhosphoSitePlus (Q8N6F7)
  Modification sites at neXtProt (NX_Q8N6F7)

• Protein Refseq
• XP_011510929.1; XP_011510931.1

• Function
• Involved in the negative regulation of lymphocyte motility.
  It mediates the migration-inhibitory effects of IL6.
  Serves as a positive regulator of the RhoA signaling pathway.
  Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK.
  Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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