Rabbit Anti-GCSAM Recombinant Antibody (clone R03-7X6) (CAT#: VS3-XY3367)
It is a recombinant rabbit antibody targeting the human GCSAM (Germinal center associated signaling and motility), which mediates the migration-inhibitory effects of IL6 and serves as a positive regulator of the RhoA signaling pathway. It has been determined using Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human GCSAM
- Species Reactivity
- Human
- Clone
- R03-7X6
- Applications
- IHC-P, ICC, IF, FC
- Related Disease
- Lymphoma; Diffuse Large B-Cell Lymphoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- HGAL; GCAT2; GCET2
- Gene ID
- 257144
- UniProt ID
- Q8N6F7
- Long Name
- Germinal center associated signaling and motility
- Cellular Localization
- Cytoplasm, Cell membrane
- Post Translation Modifications
- Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. (Q8N6F7-GCSAM_HUMAN)
Modification sites at PhosphoSitePlus (Q8N6F7)
Modification sites at neXtProt (NX_Q8N6F7)
- Protein Refseq
- XP_011510929.1; XP_011510931.1
- Function
- Involved in the negative regulation of lymphocyte motility.
It mediates the migration-inhibitory effects of IL6.
Serves as a positive regulator of the RhoA signaling pathway.
Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK.
Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1725 | Rabbit Anti-GCSAM Recombinant Antibody (clone R05-4H2) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
| VS13-YC440 | Rabbit Anti-GCSAM Recombinant Antibody (VS13-YC440) | IHC-P | Rabbit IgG |
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