Specifications

Immunogen
Recombinant human GCET2 protein

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Human GCSAM

Species Reactivity
Human

Clone
R05-4H2

Applications
Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence

MW
The calculated weight of the target protein is approximately 21 kDa, while the observed molecular weight stands at 21 kDa.

Related Disease
Lymphoma and Diffuse Large B-Cell Lymphoma

Product Property

Purification
Affinity Purified

Format
Liquid

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Germinal Center Associated Signaling And Motility; Germinal Center B-Cell-Expressed Transcript 2 Protein; Germinal Center-Associated Lymphoma Protein; Human Germinal Center-Associated Lymphoma; Germinal Center Expressed Transcript 2; GCET2

Gene ID
257144

UniProt ID
Q8N6F7

Cellular Localization
Cell membrane, Cytoplasm, Membrane

Post Translation Modifications
Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.

Protein Refseq
XP_011510929.1; XP_011510931.1; XP_011510932.1; XP_024309205.1; XP_024309206.1

Function
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.

Recommended Products

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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IgG Antibody Products

CAT	Product Name	Application	Type
VS3-XY3367	Rabbit Anti-GCSAM Recombinant Antibody (clone R03-7X6)	IHC-P, ICC, IF, FC	Rabbit IgG

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