Human Anti-GD3 Recombinant Antibody (clone KM871) (CAT#: FAMAB-0128YC)
Provided is a chimeric antibody specific for human ganglioside (GD3), designated KM871. The chimeric KM871 was more effective in killing GD3-expressing tumor cells than was the mouse counterpart KM641.
Specific Inquiry
ELISA
Figure 1 Enzyme-linked immunosorbent assay analysis of chimeric KM871.
Comparison of the reactivity with GD3 between chimeric KM871 and murine KM641.
FC
Figure 2 Flow-cytometric analysis of the cell binding of chimeric KM871 and murine KM641.
Neuroblastoma P122 cells and melanoma G361 cells were reacted with murine anti- (salmon growth hormone) mAb, KM737 (control antibody), murine KM641 and chimeric KM871. The cells were then stained with fluorescein-isothiocyanate-labeled protein Aand analyzed by flow cytometry.
FuncS
Figure 3 Antitumor effects of chimeric KM871 and murine KM641 on transplanted tumor in nude mice.
Each point represents the mean and SD from five to seven animals. Murine KM231, anti-sialyl-Le a mAb, was used as a negative control antibody.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric (mouse/human) IgG1, κ
- Specificity
- Human GD3
- Species Reactivity
- Human
- Clone
- KM871
- Applications
- ELISA, FC, Cyt
- Related Disease
- Tumor
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Ganglioside; GD3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
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Human Antibody Products
Humanized Antibody Products
Chimeric Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-049 | Human Anti-GD3 Recombinant Antibody (clone chR24) | ELISA | Chimeric (mouse/human) IgG |
| PABC-050 | Mouse Anti-GD3 Recombinant Antibody (clone R24) | ELISA | Mouse IgG |
| FAMAB-0127YC | Mouse Anti-GD3 Recombinant Antibody (clone KM641) | ELISA, FC, Cyt | Mouse IgG3, κ |
| HPAB-0001LY | Mouse Anti-GD3 Recombinant Antibody (clone 19B) | IHC, TLC immunostaining | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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