Human Anti-GD3 Recombinant Antibody (clone KM871) (CAT#: FAMAB-0128YC)
Provided is a chimeric antibody specific for human ganglioside (GD3), designated KM871. The chimeric KM871 was more effective in killing GD3-expressing tumor cells than was the mouse counterpart KM641.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
ELISA
Figure 1 Enzyme-linked immunosorbent assay analysis of chimeric KM871.
Comparison of the reactivity with GD3 between chimeric KM871 and murine KM641.
FC
Figure 2 Flow-cytometric analysis of the cell binding of chimeric KM871 and murine KM641.
Neuroblastoma P122 cells and melanoma G361 cells were reacted with murine anti- (salmon growth hormone) mAb, KM737 (control antibody), murine KM641 and chimeric KM871. The cells were then stained with fluorescein-isothiocyanate-labeled protein Aand analyzed by flow cytometry.
FuncS
Figure 3 Antitumor effects of chimeric KM871 and murine KM641 on transplanted tumor in nude mice.
Each point represents the mean and SD from five to seven animals. Murine KM231, anti-sialyl-Le a mAb, was used as a negative control antibody.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric (mouse/human) IgG1, κ
- Specificity
- Human GD3
- Species Reactivity
- Human
- Clone
- KM871
- Applications
- ELISA, FC, Cyt
- Related Disease
- Tumor
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Ganglioside; GD3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
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Human Antibody Products
Humanized Antibody Products
Chimeric Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-049 | Human Anti-GD3 Recombinant Antibody (clone chR24) | ELISA | Chimeric (mouse/human) IgG |
| PABC-050 | Mouse Anti-GD3 Recombinant Antibody (clone R24) | ELISA | Mouse IgG |
| FAMAB-0127YC | Mouse Anti-GD3 Recombinant Antibody (clone KM641) | ELISA, FC, Cyt | Mouse IgG3, κ |
| HPAB-0001LY | Mouse Anti-GD3 Recombinant Antibody (clone 19B) | IHC, TLC immunostaining | Mouse IgG |
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