Human Anti-gp100 Recombinant Soluble TCR (clone (PMEL17)-7)
CAT#: scTCR-0502YC-S(P)
Recombinant Human single-chain TCR (scTCR) PMEL17 recognizes gp100 (280–288) peptide variant YLE-9V (YLEPGPVTV) in the context of HLA-A*02:01. The scTCR is responsible for the specificity of T cells.
Specifications
- Host Species
- Human
- Target
- gp100
- Epitope
- YLEPGPVTV
- MHC
- HLA-A*02:01
- Clone
- PMEL17
- Type
- Single-Chain TCR
- Related Disease
- Melanoma
Target
- Alternative Names
- gp100 (280–288) peptide variant YLE-9V; YLEPGPVTV
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Specific To YLE-9V Variant
We needed a TCR specific for the gp100 variant YLE-9V, and the PMEL17 clone worked perfectly. It recognized the YLEPGPVTV peptide in the context of HLA-A*02:01, which was essential for our comparative peptide ligand studies.
Insight Into T-Cell Responses
This product helped us understand the impact of peptide residue substitutions. By studying the recognition of this specific variant, we gained valuable insights into polyclonal T-cell responses and the effectiveness of designer peptides.
Q&As
-
Which gp100 variant does the PMEL17 clone target?
A: The PMEL17 clone provided in this product targets the gp100 (280-288) peptide variant YLE-9V. The specific sequence is YLEPGPVTV, and it is recognized in the context of HLA-A*02:01.
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Why are designer peptides not always effective?
A: While there is emphasis on immunizing with altered peptide ligands to induce strong anti-tumor immunity, previous studies have shown that substitutions, such as at peptide residue Glu(3), can have a broad negative impact on polyclonal T-cell responses.
View the frequently asked questions answered by Creative Biolabs Support.
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| CAT | Product Name | Application | Type |
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| MHC-YF854 | DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
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| MHC-YF1006 | APC-DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
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| MHC-YF1158 | PE-DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| MHC-YF1462 | BV421-DRB1*04:01/Human gp100 (IYRRRLMKQDFSVPQLPHS) MHC Tetramer | FCM |
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