Rabbit Anti-GPX4 Recombinant Antibody (VS13-YC464) (CAT#: VS13-YC464)
The Rabbit Anti-GPX4 Recombinant Antibody is specific for human, mouse and rat GPX4. GPX4, another glutathione peroxidase family member, influences lipid peroxidation and cell protection, linked to disorders like SMDS through dual catalytic and structural roles. The anti-GPX4 antibody can be used for Western blot (1/500-1/2000), Immunohistochemistry-paraffin (1/50-1/500), Immunocytochemistry (1/50-1/200).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/58546/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/58546/if_selected.jpg
Figure 2 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47224/141864_A_8_5.jpg
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47224/141864_A_8_5.jpg
Figure 3 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47224/141864_A_6_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/47224/141864_A_6_6.jpg
Figure 4 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167468-GPX4
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167468-GPX4
Specifications
- Immunogen
- Recombinant human GPX4, aa 23-72.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat GPX4
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P, ICC, IF
- Conjugate
- NONE
- Related Disease
- Male Infertility
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/2000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/500
Immunocytochemistry (ICC): 1/50-1/200
Target
- Alternative Names
- Glutathione Peroxidase 4; Phospholipid Hydroperoxidase; EC 1.11.1.12; GSHPx-4; GPx-4; PHGPx; Phospholipid Hydroperoxide Glutathione Peroxidase, Mitochondrial; Glutathione Peroxidase 4 (Phospholipid Hydroperoxidase);
- Gene ID
- 2879
- UniProt ID
- P36969
- Long Name
- Glutathione Peroxidase 4
- Cellular Localization
- Mitochondrion; Cytoplasm
- Protein Refseq
- NP_001034936.1
- Function
- Required for normal sperm development and male fertility (By similarity).
Essential for maturation and survival of photoreceptor cells (By similarity).
Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity).
Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed:11115402).
Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "GPX4"
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
Fab Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0762MZ | Recombinant Mouse Anti-Human GPX4 Antibody (clone 8B5) | ELISA, IP, WB | Mouse antibody |
| MRO-0688-CN | Rabbit Anti-GPX4 Recombinant Antibody (clone JU11-31) | WB, IHC | Rabbit IgG |
| MRO-1906-CN | Rabbit Anti-GPX4 Polyclonal Antibody (MRO-1906-CN) | WB, IF, IHC, FC | Rabbit IgG |
| FAMAB-0367JF | Mouse Anti-GPx4 Recombinant Antibody (clone 63-1) | WB, IHC, IF | Mouse IgG2b, κ |
| VS3-XY3371 | Rabbit Anti-GPX4 Recombinant Antibody (clone R01-6I5) | WB, IHC-F, IHC-P, ICC, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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