AibGenesis™ Rabbit Anti-GRN Recombinant Antibody (AibG-Rb-GR453)
CAT#: VS-0426-FY453
Discovered via our AI-powered antibody discovery platform, this Rabbit IgG targets Progranulin (GRN). Validated for WB, IHC, and IF-P in Human samples, it is a critical tool for investigating lysosomal function, wound healing, and mutations associated with frontotemporal lobar degeneration (FTLD).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to lysosomes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8763/100_A3_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to endosomes & lysosomes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/548_F4_2_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19394/618_F6_3_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_9_8.jpg
Normal Tissue
Figure 7 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19394/43509_B_7_5.jpg
Normal Tissue
Figure 8 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_8_3.jpg
Normal Tissue
Figure 9 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28747/61533_A_9_4.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000030582-GRN
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human GRN
- Species Reactivity
- Human
- Clone
- AibG-Rb-GR453
- Applications
- Western Blot, Immunohistochemistry, Immunoprecipitation, Immunofluorescence-Paraffin
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related and Ceroid Lipofuscinosis, Neuronal, 11
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, pH 7.4, 150 mM NaCl, 50% Glycerol
- Preservative
- 0.02% New type preservative N
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:500-1:2000), Immunohistochemistry (1:200-1:1000), Immunoprecipitation (1:50-1:100), Immunofluorescence-Paraffin (1:200-1:1000)
Target
- Alternative Names
- Acrogranin; CLN11; GEP; GP88; Granulins; GRN; PCDGF; PEPI; PGRN; Proepithelin; Progranulin
- Gene ID
- 2896
- UniProt ID
- P28799
- Long Name
- Granulin Precursor
- Sequence Similarities
- Belongs to the granulin family.
- Cellular Localization
- Secreted, Lysosome
- Post Translation Modifications
- Cleaved by ELANE; proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production; granulin-3 and granulin-4 are resistant to ELANE (PubMed:12526812, 28743268).
Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome (PubMed:28743268).
Glycosylation at Asn265, Asn118, Thr182, Asn368, Asn236, Asn530, and Thr532 (NX_P28799 [NX_P28799-1])
Modification sites at PhosphoSitePlus (P28799)
Glycosylation from GlyConnect GRN_HUMAN (1290)
Glycosylation from GlyGen (P28799) 9 sites, 5 N-linked glycans (1 site), 5 O-linked glycans (3 sites)
- Protein Refseq
- NP_002078.1
- Function
- In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GRN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2578z | Mouse Anti-GRN Recombinant Antibody (clone 5B10) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1403MZ | Recombinant Mouse Anti-Human GRN Antibody (clone 1F5) | ICC, IF, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1521 | Rabbit Anti-GRN Recombinant Antibody (clone DS1521AB) | ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1522 | Rabbit Anti-Grn Recombinant Antibody (clone DS1522AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY954 | Anti-GRN Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC474 | CytoStream™ Rabbit Anti-GRN Recombinant Antibody (VS13-YC474) | WB, IHC-P, ICC, IF, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2938 | Anti-Mouse Grn Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2937 | Anti-Human GRN Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC5 | SmartAb™ Recombinant Anti-GRN pH-dependent Antibody (VS-0825-YC5) | ELISA | Human IgG |
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