Recombinant Human Anti-H7N9 HA Antibody (m826) (CAT#: PABC-427)

Figure 1 ADCC activity of m826 and CR9114 IgG against H7N9 HA expressing-293 T cells mediated by freshly prepared human PBMCs.

The percentage (%) of specific lysis was calculated as described in the Materials and Methods. All error bars reflect standard deviation (s.d.).

Yu, F., Song, H., Wu, Y., Chang, S. Y., Wang, L., Li, W., ... & Feng, Y. (2017). A potent germline-like human monoclonal antibody targets a pH-sensitive epitope on H7N9 influenza hemagglutinin. Cell host & microbe, 22(4), 471-483.

Figure 2 Prophylactic efficacy of mAb m826 in protecting mice against lethal dose H7N9 challenge.

For prophylactic efficacy study, mice were treated (i.p.) with m826 antibody 12 h before viral challenge (i.n.) with 10x LD₅₀ of H7N9 virus and were monitored daily for 14 days for the accumulated mortality (A) and weight loss (B), expressed as percent (%) weight loss and survival, respectively (n = 5 per group). PBS was used for the control group.

Yu, F., Song, H., Wu, Y., Chang, S. Y., Wang, L., Li, W., ... & Feng, Y. (2017). A potent germline-like human monoclonal antibody targets a pH-sensitive epitope on H7N9 influenza hemagglutinin. Cell host & microbe, 22(4), 471-483.

Figure 3 The immunostaining-based neutralization assay for m826 mAb against H7N4 virus.

Immunostaining was conducted using influenza NP-specific mAbs to detect virus-infected cells. H7N4-specfic Ab was used as positive control.

Yu, F., Song, H., Wu, Y., Chang, S. Y., Wang, L., Li, W., ... & Feng, Y. (2017). A potent germline-like human monoclonal antibody targets a pH-sensitive epitope on H7N9 influenza hemagglutinin. Cell host & microbe, 22(4), 471-483.