Human Anti-HCMV gB Recombinant Antibody (clone SM10) (CAT#: FAMAB-0142JF)
Recombinant monoclonal antibody specially binds to domain I of glycoprotein B (gB) of human cytomegalovirus (HCMV). This human anti-gB antibody (SM10) could be useful for the treatment of HCMV infections.
Specific Inquiry
WB
Figure 1 Cell surface expression of gp55-116 (gB).
Viable uninfected HF or HCMV AD169-infected HF cells were radioiodinated, solubilized, and immune precipitated as described.
Britt, W. J., Vugler, L., Butfiloski, E. J., & Stephens, E. B. (1990). Cell surface expression of human cytomegalovirus (HCMV) gp55-116 (gB): use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody response. Journal of virology, 64(3), 1079-1085.
Neut
Figure 2 Depletion of HCMV neutralizing activity by HeLa cells expressing gp55-116 (gB).
Various numbers of VVPED8-infected cells were incubated with monoclonal antibody.
Britt, W. J., Vugler, L., Butfiloski, E. J., & Stephens, E. B. (1990). Cell surface expression of human cytomegalovirus (HCMV) gp55-116 (gB): use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody response. Journal of virology, 64(3), 1079-1085.
ELISA
Figure 3 ELISA analysis of purified HCMV in serum samples.
Each value represents the mean ± S.E.M. of duplicate measurements from at least four independent experiments.
Endresz, V., Kari, L., Berencsi, K., Kari, C., Gyulai, Z., Jeney, C., ... & Gönczöl, E. (1999). Induction of human cytomegalovirus (HCMV)-glycoprotein B (gB)-specific neutralizing antibody and phosphoprotein 65 (pp65)-specific cytotoxic T lymphocyte responses by naked DNA immunization. Vaccine, 17(1), 50-58.
Specifications
- Host Species
- Human
- Type
- Human IgG3, κ
- Specificity
- HCMV gB
- Species Reactivity
- HCMV
- Clone
- SM10
- Applications
- WB, ELISA, Neut
- Related Disease
- HCMV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The TBEV antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Neutralization.
Target
- Alternative Names
- Human Cytomegalovirus; HCMV; Human Cytomegalovirus envelope glycoprotein B; HCMV gB
- Gene ID
- 3077424
- UniProt ID
- F5HB53
- Function
- Neutralization
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone SM10"
See other products for "HCMV GB"
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-443-F(E) | Recombinant Anti-HCMV GB Antibody Fab Fragment | WB, IF, FuncS | Fab |
| MHH-443-F(E) | Recombinant Human Anti-HCMV GB Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| FAMAB-0142JF-F(E) | Human Anti-HCMV gB Recombinant Antibody (clone SM10); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| FAMAB-0143JF-F(E) | Human Anti-HCMV gB Recombinant Antibody (clone 1G2); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| FAMAB-0144JF-F(E) | Human Anti-HCMV gB Recombinant Antibody (clone 2C2); Fab Fragment | WB, ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-443-S(P) | Recombinant Anti-HCMV GB Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| FAMAB-0142JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone SM10); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0143JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone 1G2); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0144JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone 2C2); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0145JF-S(P) | Human Anti-HCMV gB Recombinant Antibody (clone SM1-6); scFv Fragment | WB, ELISA, FuncS | Human scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1032LC | Anti-HCMV gB Recombinant Antibody (TI-23) | ELISA | Humanized antibody |
| MRO-1032LC-S(P) | Anti-HCMV gB Recombinant Antibody scFv Fragment (TI-23) | ELISA | Humanized antibody |
| MRO-1032LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (TI-23) | ELISA | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1033LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C1) | ELISA | Human antibody |
| MRO-1034LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C3) | ELISA | Human antibody |
| MRO-1035LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C4) | ELISA | Human antibody |
| MRO-1036LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C7) | ELISA | Human antibody |
| MRO-1037LC-F(E) | Anti-HCMV gB Recombinant Antibody Fab Fragment (C23) | ELISA | Human antibody |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1438LC | Recombinant Human Anti-HCMV gB Antibody (MAb C23) | WB | IgG1 |
| EPAF-1497LC | Recombinant Mouse Anti-HCMV gB Antibody (CH28-2) | ELISA |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0173CQ | Recombinant Mouse Anti-HCMV gB Antibody (7-17) | ELISA, Neut | Mouse IgG3, κ |
| HPAB-0639-CN | Recombinant Human Anti-HCMV gB Antibody (2F10) | ELISA, Neut | Human IgG |
| HPAB-0640-CN | Recombinant Human Anti-HCMV gB Antibody (2M16) | ELISA, Neut | Human IgG |
| HPAB-0641-CN | Recombinant Human Anti-HCMV gB Antibody (2N9) | ELISA, Neut | Human IgG |
| HPAB-0642-CN | Recombinant Human Anti-HCMV gB Antibody (4P12) | ELISA, Neut | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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