Mouse Anti-HDAC2 Recombinant Antibody (VS3-FY2733) (CAT#: VS3-FY2733)
This is a recombinant mouse IgG monoclonal antibody that is specifically created to bind human HDAC2 protein. It cross-reacts with mouse, rat and monkey. Its application extends to the research of Pulmonary Disease, Chronic Obstructive and Rett Syndrome.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11727/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11727/if_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/if_selected.jpg
Figure 3 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows strong nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/ihc_selected.jpg
(Immunohistochemical staining of human hippocampus shows strong nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/ihc_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/17525_A_8_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/17525_A_8_8.jpg
Figure 5 Cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/17525_B_7_5.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/17525_B_7_5.jpg
Figure 6 Salivary gland
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/17525_B_2_1.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/17525_B_2_1.jpg
Figure 7 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/17525_A_9_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5054/17525_A_9_5.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196591-HDAC2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196591-HDAC2
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Histone deacetylase 2 of human, mouse, rat and monkey origins
- Species Reactivity
- Human, Mouse, Rat, Monkey
- Applications
- WB, ICC
- Conjugate
- Unconjugated, FITC
- Related Disease
- Pulmonary Disease, Chronic Obstructive and Rett Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunocytochemistry: 1/50-1/200
Target
- Alternative Names
- Histone Deacetylase 2; EC 3.5.1.98; HD2; Transcriptional Regulator Homolog RPD3; YY1-Associated Factor 1; RPD3; YAF1
- Gene ID
- 3066
- UniProt ID
- Q92769
- Sequence Similarities
- Belongs to the histone deacetylase family. HD type 1 subfamily.
- Cellular Localization
- Nucleus
Cytoplasm
- Post Translation Modifications
- S-nitrosylated by GAPDH.
In neurons, S-nitrosylation at Cys-262 and Cys-274 does not affect enzyme activity, but induces HDAC2 release from chromatin.
This in turn increases acetylation of histones surrounding neurotrophin-dependent gene promoters and promotes their transcription.
In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching.
Ubiquitination at Lys11, Lys67, Lys75, Lys243, Lys284, and Lys362
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_047274648.1; XP_054211242.1; NP_001518.3
- Function
- May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity).
Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
Alcoholism
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2296CT | Recombinant Mouse anti-Human HDAC2 Monoclonal antibody (FQS5045) | IHC-P, WB, IP, ChIP, ICC/IF | |
| MRO-0718-CN | Rabbit Anti-HDAC2 Recombinant Antibody (clone CBACN-257) | WB, IF, IHC, IP, FC | Rabbit IgG |
| MRO-0719-CN | Rabbit Anti-HDAC2 Recombinant Antibody (clone CBACN-258) | WB, IP | Rabbit IgG |
| VS3-WK1085 | Mouse Anti-HDAC2 Recombinant Antibody (VS3-WK1085) | WB | Mouse IgG1 |
| VS3-WK1086 | Rabbit Anti-HDAC2 Recombinant Antibody (VS3-WK1086) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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