Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone B12) (CAT#: HPAB-0079-WJ)

This product is a mouse milk-expressed human IgA2 antibody derived from b12 (IgG1) antibody, targeting CD4 binding site of HIV glycoprotein, gp120.


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ELISA

Figure 1 ELISA binding curves of scFv mAb.

Figure 1 ELISA binding curves of scFv mAb.

IgG 2G12 (squares) against native (filled symbols) and denatured (open symbols) gp120JR-FL.

Zwick, M. B., Kelleher, R., Jensen, R., Labrijn, A. F., Wang, M., Quinnan, G. V., ... & Burton, D. R. (2003). A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12. Journal of virology , 77 (12), 6965-6978.

Inhib

Figure 2 Effect of 4KG5 as an inhibitor of biotinylated sCD4 and of various MAbs against gp120JR-FL.

Figure 2 Effect of 4KG5 as an inhibitor of biotinylated sCD4 and of various MAbs against gp120JR-FL.

In each case, a concentration of biotinylated agent previously determined to result in approximately 75% of the maximal signal (∼0.03 μg/ml) was used.

Zwick, M. B., Kelleher, R., Jensen, R., Labrijn, A. F., Wang, M., Quinnan, G. V., ... & Burton, D. R. (2003). A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12. Journal of virology , 77 (12), 6965-6978.


Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgA2
  • Specificity
  • HIV gp 120
  • Species Reactivity
  • HIV
  • Clone
  • B12
  • Applications
  • ELISA, Inhib
  • Related Disease
  • HIV infection

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The HIV-1 gp120 antibody has been reported in applications of Inhibition, Enzyme-linked Immunosorbent Assay.

Target

  • Alternative Names
  • Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120; gp120; HIV envelope

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone b12"

See other products for "HIV-1 gp120"

Single-domain Antibody

Chimeric Antibody

CAT Product Name Application Type
MRO-135LC Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) ELISA, WB, Neut Chimeric antibody (mouse/human)
MRO-135LC-S(P) Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) ELISA, WB Chimeric antibody (mouse/human)
MRO-135LC-F(E) Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) ELISA, WB Chimeric antibody (mouse/human)

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4220 Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) WB, ELISA Rabbit IgG

Humanized Antibody

CAT Product Name Application Type
PABX-101-S(P) Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment WB, ELISA, FuncS Human scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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