Human Anti-HIV-1 gp160 Recombinant Antibody (clone 10-188) (CAT#: MRO-3675CQ)
Recombinant human antibody to gp160(307-320). 10-188 antibody neutralized 100% of Tier-1 HIV viruses and 19% of Tier-2 HIV viruses tested.
Specific Inquiry
Neut
Figure 1 Neutralizing activity of HIV-gp120/41 BiAbs.
Graph shows neutralization curves of SS1196.1 pseudovirus for 10-188 BiAb and controls. The x axis shows the antibody concentration (nM) required to achieve 50% neutralization (IC50), indicated by the dashed line.
Mouquet, H., Warncke, M., Scheid, J. F., Seaman, M. S., & Nussenzweig, M. C. (2012). Enhanced HIV-1 neutralization by antibody heteroligation. Proceedings of the National Academy of Sciences of the United States of America, 109(3), 875-880.
WB
Figure 2 Design and production of HIV-gp120/41 BiAbs.
Western blot analyses of gp120/41 BiAbs and BiAb controls (anti-gp120/mGO53 heterodimers).
Mouquet, H., Warncke, M., Scheid, J. F., Seaman, M. S., & Nussenzweig, M. C. (2012). Enhanced HIV-1 neutralization by antibody heteroligation. Proceedings of the National Academy of Sciences of the United States of America, 109(3), 875-880.
ELISA
Figure 3 Design and production of HIV-gp120/41 BiAbs.
Binding analyses of 10-188 IgG antibody and scFv2-Fc control to gp120 antigen measured by ELISA. The x axis shows the antibody concentration (nM) required to obtain the ELISA values (OD405 nm) indicated on the y axis.
Mouquet, H., Warncke, M., Scheid, J. F., Seaman, M. S., & Nussenzweig, M. C. (2012). Enhanced HIV-1 neutralization by antibody heteroligation. Proceedings of the National Academy of Sciences of the United States of America, 109(3), 875-880.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Recognizes HIV-1 gp160(307-320)
- Species Reactivity
- HIV-1
- Clone
- 10-188
- Applications
- Neut, WB, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Neutralization and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP160; gp160; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-382 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08) | Neut, FuncS | Human IgG, κ |
| PABL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01) | FC, Neut | Human IgG |
| PABL-555 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02) | FC, Neut | Human IgG |
| PABL-556 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-556) | Neut | Human IgG |
| PABL-557 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01) | FC, Neut | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); scFv Fragment | ELISA, Neut | Human scFv |
| MRO-3832CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 4D7/4); Fab Fragment | ELISA, FC | Mouse Fab |
| MRO-3833CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 5B3); Fab Fragment | ELISA, Block | Mouse Fab |
| MRO-3834CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 5C2E5); Fab Fragment | Block | Mouse Fab |
| MRO-3835CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 5F4/1); Fab Fragment | ELISA, FC | Mouse Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-086LC | Anti-HIV-1 gp160 Recombinant Antibody (1C1) | ELISA | Mouse antibody |
| MRO-087LC | Anti-HIV-1 gp160 Recombinant Antibody (1H9) | ELISA | Mouse antibody |
| MRO-086LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1C1) | ELISA | Mouse antibody |
| MRO-087LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1H9) | ELISA | Mouse antibody |
| MRO-088LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (2D7) | ELISA | Mouse antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-100LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (N7019b) | ELISA | Human antibody |
| MRO-101LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (K24-3b) | ELISA | Human antibody |
| MRO-075LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (24G3) | ELISA | Human antibody |
| MRO-080LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (81C7) | ELISA | Human antibody |
| MRO-091LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (MAb CL1) | ELISA | Human antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3885CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone PC5009); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3886CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone μ5.5 (5.5, mu5.5, Rμ5.5)); scFv Fragment | Neut | Mouse scFv |
| MRO-3887CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone T32); scFv Fragment | ELISA, Block | Mouse scFv |
| MRO-3888CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone T11); scFv Fragment | ELISA, Block | Mouse scFv |
| MRO-3889CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 5B2); scFv Fragment | ELISA, WB | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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