Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 2D3 (419 2D3)) (CAT#: MRO-3829CQ)
Recombinant mouse antibody to gp160(419-439). 2D3 also binds to native but not denatured gp120.
Specific Inquiry
Inhib
Figure 1 MAbs 11A8 and 2D3 compete for binding to gp120.
Binding to gp120 of biotinylated 2D3 in the presence of unconjugated MAbs 2D3 or 11A8 was evaluated in ELISA.
Kelker, H. C., Itri, V. R., & Valentine, F. T. (2010). A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein. PLoS One, 5(1).
ELISA
Figure 2 Antibodies elicited by MCPs fail to recognize denatured gp120.
All sera and MAb preparations were diluted as indicated in the Figure.
Kelker, H. C., Itri, V. R., & Valentine, F. T. (2010). A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein. PLoS One, 5(1).
FC
Figure 3 A MAb elicited by 426 MCP (11A8) recognizes HIV-1 on the surface of infected cells.
Antibody binding was detected using PE conjugated secondary antibody and measured by flow cytometry. Flow histogram plots are displayed.
Kelker, H. C., Itri, V. R., & Valentine, F. T. (2010). A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein. PLoS One, 5(1).
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Recognizes HIV-1 gp160(419-439)
- Species Reactivity
- HIV-1
- Clone
- 2D3 (419 2D3)
- Applications
- ELISA, FC, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp160 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Flow Cytometry, Inhibition. ELISA: Protein concentration of the stock of undiluted MAb preparations used was, respectively: 1.96 mg/ml (MAb 11A8), and 0.5 mg/ml (MAb 2D3).
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP160; gp160; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01) | FC, Neut | Human IgG |
| PABL-555 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02) | FC, Neut | Human IgG |
| PABL-556 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-556) | Neut | Human IgG |
| PABL-557 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01) | FC, Neut | Human IgG |
| PABW-163 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 268-D) | ELISA, Neut | Human IgG1,λ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-551 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01); Fab Fragment | Neut | Human Fab |
| PFBL-552 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02); Fab Fragment | Neut | Human Fab |
| PFBL-553 | Human Anti-HIV-1 gp160 Recombinant Antibody; Fab Fragment (PFBL-553) | Neut | Human Fab |
| PFBL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01); Fab Fragment | Neut | Human Fab |
| MRO-3832CQ-F(E) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 4D7/4); Fab Fragment | ELISA, FC | Mouse Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-086LC | Anti-HIV-1 gp160 Recombinant Antibody (1C1) | ELISA | Mouse antibody |
| MRO-087LC | Anti-HIV-1 gp160 Recombinant Antibody (1H9) | ELISA | Mouse antibody |
| MRO-086LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1C1) | ELISA | Mouse antibody |
| MRO-087LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1H9) | ELISA | Mouse antibody |
| MRO-088LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (2D7) | ELISA | Mouse antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-075LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (24G3) | ELISA | Human antibody |
| MRO-080LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (81C7) | ELISA | Human antibody |
| MRO-091LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (MAb CL1) | ELISA | Human antibody |
| MRO-100LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (N7019b) | ELISA | Human antibody |
| MRO-101LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (K24-3b) | ELISA | Human antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3767CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone m66S28LCH-G30LCK); scFv Fragment | Neut | Human scFv |
| MRO-3768CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone m66.6 Y100cHCS); scFv Fragment | ELISA, Neut | Human scFv |
| MRO-3769CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1131-A); scFv Fragment | ELISA, WB | Human scFv |
| MRO-3771CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1A1); scFv Fragment | ELISA, WB | Human scFv |
| MRO-3772CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 4D4); scFv Fragment | ELISA, WB | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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