Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone G3-299) (CAT#: MRO-3890CQ)
Recombinant mouse antibody to gp160(429-438). The antibody binds with higher affinity to monomer than to oligomer, slow association rate, although faster than other C4 MAbs tested, with more potent neutralization of lab strain.
Specific Inquiry
ELISA
Figure 1 ELISA binding curves of select anti-gp120 Abs against full-length and loop-deleted constructs of gp140JR-FL.
Full-length (diamonds), V1-deleted (squares), V2-deleted (triangles), and V3-deleted (x) gp140JR-FL were captured via the C-terminal region of gp120 with the sheep Ab D7324 and probed with pooled G3-299.
Zwick, M. B., Kelleher, R., Jensen, R., Labrijn, A. F., Wang, M., Quinnan, G. V., ... & Burton, D. R. (2003). A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12. Journal of virology, 77(12), 6965-6978.
Inhib
Figure 2 ELISA inhibition curves of 4KG5 with various MAbs against gp120JR-FL.
A concentration of 4KG5 previously determined to result in approximately 75% of the maximal signal (∼0.3 μg/ml) was coincubated with various concentrations of b12 Fab (squares), b12 IgG (open diamonds), b6 Fab (circles), sCD4 (triangle), AH48 Fab (filled diamonds), or G3-4 IgG (X), and the level of 4KG5 binding to immobilized gp120JR-FL was measured via the hexahistidine tag of 4KG5 by using the India-HIS probe (Pierce) as a secondary reagent.
Zwick, M. B., Kelleher, R., Jensen, R., Labrijn, A. F., Wang, M., Quinnan, G. V., ... & Burton, D. R. (2003). A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12. Journal of virology, 77(12), 6965-6978.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Recognizes HIV-1 gp160(429-438)
- Species Reactivity
- HIV-1
- Clone
- G3-299
- Applications
- ELISA, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp160 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Inhibition.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP160; gp160; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01) | FC, Neut | Human IgG |
| PABL-555 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02) | FC, Neut | Human IgG |
| PABL-556 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-556) | Neut | Human IgG |
| PABL-557 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01) | FC, Neut | Human IgG |
| PABC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558) | ELISA, Neut | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); scFv Fragment | ELISA, Neut | Human scFv |
| MRO-3768CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone m66.6 Y100cHCS); Fab Fragment | ELISA, Neut | Human Fab |
| MRO-3769CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1131-A); Fab Fragment | ELISA, WB | Human Fab |
| MRO-3771CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1A1); Fab Fragment | ELISA, WB | Human Fab |
| MRO-3772CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 4D4); Fab Fragment | ELISA, WB | Human Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-075LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (24G3) | ELISA | Human antibody |
| MRO-080LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (81C7) | ELISA | Human antibody |
| MRO-091LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (MAb CL1) | ELISA | Human antibody |
| MRO-075LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (24G3) | ELISA | Human antibody |
| MRO-080LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (81C7) | ELISA | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-086LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1C1) | ELISA | Mouse antibody |
| MRO-087LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1H9) | ELISA | Mouse antibody |
| MRO-088LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (2D7) | ELISA | Mouse antibody |
| MRO-086LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1C1) | ELISA | Mouse antibody |
| MRO-087LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1H9) | ELISA | Mouse antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3955CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone GV4H3); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3956CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone GV1G2); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3957CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone 902 (H902)); scFv Fragment | Neut | Mouse scFv |
| MRO-3958CQ-S(P) | Mouse Anti-HIV-1 gp160 Recombinant Antibody (clone M86); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-4017CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone 11/41e); scFv Fragment | Neut | Rat scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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