Human Anti-HLA-B27 Recombinant Antibody (clone HD6); Fab Fragment (CAT#: HPAB-J0122-YC-F(E))
Provided is an antibody, which binds to HLA-B27 heavy-chain homodimers, termed HC-B27, HLA-B272 or B272, particularly recognizing B272 homodimers and which does not recognize or bind HLA-B27 heterotrimers (B27) including HLA-B27 heterotrimers with β2 microglobulin and peptide. It has shown that HD6 bound to recombinant B272 complexes but not to HLA-A2, B7 or B27 complexes in ELISA. HD6 inhibited binding of B272 to KIR3DL1, KIR3DL2 and LILRB2 immunoreceptors and B272-mediated survival and proliferation of human NK cells expressing KIR3DL2.
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human HLA-B27
- Species Reactivity
- Human
- Clone
- HD6
- Applications
- ELISA, FC
- Related Disease
- ankylosing spondylitis (AS) and reactive arthritis (ReA or Reiter's syndrome)
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Human leukocyte antigen (HLA) B27; B*2701-2759
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone HD6"
See other products for "HLA-B27"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-093CT | Human Anti-HLA-B27 Recombinant Antibody (TAB-093CT) | ELISA, Neut, FC | Human IgG |
| TAB-093CT-S(P) | Human Anti-HLA-B27 Recombinant Antibody; scFv Fragment (TAB-093CT-S(P)) | ELISA, Neut, FC | Human scFv |
| TAB-093CT-F(E) | Human Anti-HLA-B27 Recombinant Antibody; Fab Fragment (TAB-093CT-F(E)) | ELISA, Neut, FC | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP099-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC) | FC, Block | Human IgG |
| HPAB-AP100-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC) | FC, Activ | Human IgG |
| HPAB-AP101-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC) | FC, Block | Human IgG |
| HPAB-J0121-YC | Human Anti-HLA-B27 Recombinant Antibody (clone HD5) | ELISA, Block, WB, FC, IP | Human IgG1 |
| HPAB-J0122-YC | Human Anti-HLA-B27 Recombinant Antibody (clone HD6) | FC, Block, Inhib | Human IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP099-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC-S(P)); scFv Fragment | FC, Block | Human scFv |
| HPAB-AP100-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC-S(P)); scFv Fragment | FC, Activ | Human scFv |
| HPAB-AP101-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC-S(P)); scFv Fragment | FC, Block | Human scFv |
| HPAB-J0121-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (clone HD5); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0122-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (clone HD6); scFv Fragment | ELISA, FC | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP099-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC-F(E)); Fab Fragment | FC, Block | Human Fab |
| HPAB-AP100-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC-F(E)); Fab Fragment | FC, Activ | Human Fab |
| HPAB-AP101-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC-F(E)); Fab Fragment | FC, Block | Human Fab |
| HPAB-J0121-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (clone HD5); Fab Fragment | ELISA, FC | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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