Human Anti-HLA-B27 Recombinant Antibody (clone HD6)
CAT#: HPAB-J0122-YC
Provided is an antibody, which recognizes HLA-B27 heavy-chain homodimers, termed HC-B27, HLA-B272 or B272, particularly recognizing B272 homodimers and which does not recognize or bind HLA-B27 heterotrimers (B27) including HLA-B27 heterotrimers with β2 microglobulin and peptide. It binds to recombinant B272 complexes but not to HLA-A2, B7 or B27 complexes in ELISA. It could inhibit binding of B272 to KIR3DL1, KIR3DL2 and LILRB2 immunoreceptors and B272-mediated survival and proliferation of human NK cells expressing KIR3DL2.
Published Data
FC
Figure 1 Flow cytometric (FACS) analysis of HD6 binding to untransfected LBL721.220 cells.
Inhib
Figure 2 HD6 Inhibited B272 Binding to KIR3DL1, KIR3DL2 and LILRB2 Receptors.
Block
Figure 3 Inhibits Apoptosis of KIR3DL2+ Natural Killer Cells Ex Vivo; this Effect is Blocked by HD6.
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Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human HLA-B27
- Species Reactivity
- Human
- Clone
- HD6
- Applications
- FC, Block, Inhib
- Related Disease
- ankylosing spondylitis (AS) and reactive arthritis (ReA or Reiter's syndrome)
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Blocking, Inhibition and Flow Cytometry.
Target
- Alternative Names
- Human leukocyte antigen (HLA) B27; B*2701-2759
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# HPAB-J0122-YC, RRID: AB_3111434)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone HD6"
- CAT
- Product Name
See other products for "HLA-B27"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-093CT | Human Anti-HLA-B27 Recombinant Antibody (TAB-093CT) | ELISA, Neut, FC | Human IgG |
| TAB-093CT-S(P) | Human Anti-HLA-B27 Recombinant Antibody; scFv Fragment (TAB-093CT-S(P)) | ELISA, Neut, FC | Human scFv |
| TAB-093CT-F(E) | Human Anti-HLA-B27 Recombinant Antibody; Fab Fragment (TAB-093CT-F(E)) | ELISA, Neut, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP099-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC) | FC, Block | Human IgG |
| HPAB-AP100-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC) | FC, Activ | Human IgG |
| HPAB-AP101-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC) | FC, Block | Human IgG |
| HPAB-J0121-YC | Human Anti-HLA-B27 Recombinant Antibody (clone HD5) | ELISA, Block, WB, FC, IP | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP099-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC-S(P)); scFv Fragment | FC, Block | Human scFv |
| HPAB-AP100-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC-S(P)); scFv Fragment | FC, Activ | Human scFv |
| HPAB-AP101-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC-S(P)); scFv Fragment | FC, Block | Human scFv |
| HPAB-J0121-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (clone HD5); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0122-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (clone HD6); scFv Fragment | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP099-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC-F(E)); Fab Fragment | FC, Block | Human Fab |
| HPAB-AP100-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC-F(E)); Fab Fragment | FC, Activ | Human Fab |
| HPAB-AP101-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC-F(E)); Fab Fragment | FC, Block | Human Fab |
| HPAB-J0121-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (clone HD5); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-J0122-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (clone HD6); Fab Fragment | ELISA, FC | Human Fab |
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