Provided is an antibody, which recognizes HLA-B27 heavy-chain homodimers, termed HC-B27, HLA-B272 or B272, particularly recognizing B272 homodimers and which does not recognize or bind HLA-B27 heterotrimers (B27) including HLA-B27 heterotrimers with β2 microglobulin and peptide. It binds to recombinant B272 complexes but not to HLA-A2, B7 or B27 complexes in ELISA. It could inhibit binding of B272 to KIR3DL1, KIR3DL2 and LILRB2 immunoreceptors and B272-mediated survival and proliferation of human NK cells expressing KIR3DL2.
Figure 1 Flow cytometric (FACS) analysis of HD6 binding to untransfected LBL721.220 cells.
Figure 2 HD6 Inhibited B272 Binding to KIR3DL1, KIR3DL2 and LILRB2 Receptors.
Figure 3 Inhibits Apoptosis of KIR3DL2+ Natural Killer Cells Ex Vivo; this Effect is Blocked by HD6.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-093CT | Human Anti-HLA-B27 Recombinant Antibody (TAB-093CT) | ELISA, Neut, FC | Human IgG |
TAB-093CT-S(P) | Human Anti-HLA-B27 Recombinant Antibody; scFv Fragment (TAB-093CT-S(P)) | ELISA, Neut, FC | Human scFv |
TAB-093CT-F(E) | Human Anti-HLA-B27 Recombinant Antibody; Fab Fragment (TAB-093CT-F(E)) | ELISA, Neut, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP099-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC) | FC, Block | Human IgG |
HPAB-AP100-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC) | FC, Activ | Human IgG |
HPAB-AP101-YC | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC) | FC, Block | Human IgG |
HPAB-J0121-YC | Human Anti-HLA-B27 Recombinant Antibody (clone HD5) | ELISA, Block, WB, FC, IP | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP099-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC-S(P)); scFv Fragment | FC, Block | Human scFv |
HPAB-AP100-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC-S(P)); scFv Fragment | FC, Activ | Human scFv |
HPAB-AP101-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC-S(P)); scFv Fragment | FC, Block | Human scFv |
HPAB-J0121-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (clone HD5); scFv Fragment | ELISA, FC | Human scFv |
HPAB-J0122-YC-S(P) | Human Anti-HLA-B27 Recombinant Antibody (clone HD6); scFv Fragment | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP099-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP099-YC-F(E)); Fab Fragment | FC, Block | Human Fab |
HPAB-AP100-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP100-YC-F(E)); Fab Fragment | FC, Activ | Human Fab |
HPAB-AP101-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (HPAB-AP101-YC-F(E)); Fab Fragment | FC, Block | Human Fab |
HPAB-J0121-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (clone HD5); Fab Fragment | ELISA, FC | Human Fab |
HPAB-J0122-YC-F(E) | Human Anti-HLA-B27 Recombinant Antibody (clone HD6); Fab Fragment | ELISA, FC | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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