Human Anti-HLA-B27 Recombinant Antibody (clone HD6) (CAT#: HPAB-J0122-YC)
Provided is an antibody, which recognizes HLA-B27 heavy-chain homodimers, termed HC-B27, HLA-B272 or B272, particularly recognizing B272 homodimers and which does not recognize or bind HLA-B27 heterotrimers (B27) including HLA-B27 heterotrimers with β2 microglobulin and peptide. It binds to recombinant B272 complexes but not to HLA-A2, B7 or B27 complexes in ELISA. It could inhibit binding of B272 to KIR3DL1, KIR3DL2 and LILRB2 immunoreceptors and B272-mediated survival and proliferation of human NK cells expressing KIR3DL2.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FC
Figure 1 Flow cytometric (FACS) analysis of HD6 binding to untransfected LBL721.220 cells.
Inhib
Figure 2 HD6 Inhibited B272 Binding to KIR3DL1, KIR3DL2 and LILRB2 Receptors.
Block
Figure 3 Inhibits Apoptosis of KIR3DL2+ Natural Killer Cells Ex Vivo; this Effect is Blocked by HD6.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human HLA-B27
- Species Reactivity
- Human
- Clone
- HD6
- Applications
- FC, Block, Inhib
- Related Disease
- ankylosing spondylitis (AS) and reactive arthritis (ReA or Reiter's syndrome)
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Blocking, Inhibition and Flow Cytometry.
Target
- Alternative Names
- Human leukocyte antigen (HLA) B27; B*2701-2759
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-093CT | Human Anti-HLA-B27 Recombinant Antibody (TAB-093CT) | ELISA, Neut, FC | Human IgG |
| TAB-093CT-S(P) | Human Anti-HLA-B27 Recombinant Antibody; scFv Fragment (TAB-093CT-S(P)) | ELISA, Neut, FC | Human scFv |
| TAB-093CT-F(E) | Human Anti-HLA-B27 Recombinant Antibody; Fab Fragment (TAB-093CT-F(E)) | ELISA, Neut, FC | Human Fab |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# HPAB-J0122-YC, RRID: AB_3111434)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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