Human Anti-HYOU1 Recombinant Antibody (clone c5F4-hIgG1) (CAT#: HPAB-AP850-YC)
Provided are novel antibodies that specifically bind to an ORP150 polypeptide expressed of the cell surface of plasmacytoma, multiple myeloma, colorectal cancer cells, gastric cancer cells, or esophageal cancer cells. These antibodies can be used in a variety of diagnostic and therapeutic methods.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FuncS
Figure 1 5F4 antibodies (c5F4-hIgG1, c5F4-hIgG2, c5F4-hIgG3, and c5F4-hIgG4) induced apoptosis of human plasmacytoma cell line U266 in vitro.
U266 cells were incubated with human Ig (a human Ig mixture, Scottish National Transfusion Service, Cat#F000685) or a chimeric 5F4 antibody at 1 ug/ml, 3 ug/ml, 10 ug/ml or 30 ug/ml in the presence of cross-linker (AffinityPure mouse anti-human IgG Fcγ fragment specific, Jackson ImmunoResearch, Cat#209-005-098) for 6 hours. At the end of the incubation, cells were stained with Yo-Pro-1 and the percentage of stained cells was measured using FACS analysis.
FuncS
Figure 2 Suppression of multiple myeloma tumor growth in SCID mice by a humanized 5F4 antibody.
Mice were implanted subcutaneously with L363 cells and treated intraperitoneally with humanized 5F4Ac.2/v17 or a control human IgG at 20 mg/kg three times weekly. Tumor volume was determined at day 5, 7, 9, 14, 16, 19, 21 and 23 after tumor implantation.
Specifications
- Immunogen
- The RPMI8226 cell membrane
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human HYOU1
- Species Reactivity
- Human
- Clone
- c5F4-hIgG1
- Applications
- FuncS
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
- Alternative Names
- Hypoxia Up-Regulated 1; 170 KDa Glucose-Regulated Protein; 150 KDa Oxygen-Regulated Protein; GRP-170; ORP-150; Grp170
- Gene ID
- 10525
- UniProt ID
- Q9Y4L1
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1719 | Rabbit Anti-HYOU1 Recombinant Antibody (clone DS1719AB) | WB, IHC, ICC, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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