AbPlus™ Anti-IDH1 Magnetic Beads (VS-0724-YC1486)
CAT#: VS-0724-YC1486
The AbPlus Anti-IDH1 Magnetic Beads (VS-0724-YC1486) is an innovative affinity resin which is bound with anti-IDH1 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of IDH1 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nuclear bodies & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62556/1538_D1_6_selected.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35248/142542_A_7_4.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35248/142542_A_6_6.jpg
Normal Tissue
Figure 4 Prostate
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35248/142542_A_1_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Hep G2, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138413-IDH1
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-IDH1 specific antibody
- Target
- IDH1
- Immunogen
- Recombinant human Isocitrate dehydrogenase/IDH1 fragment derived from E. coli.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
- Alternative Names
- Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic
- Gene ID
- 3417
- UniProt ID
- O75874
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IDH1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1615z | Mouse Anti-IDH1 Recombinant Antibody (clone 27C2) | WB, FC, IF, IHC | Mouse IgG1, κ |
| HPAB-0136-YC | Mouse Anti-IDH1 Recombinant Antibody (clone A2E8) | ELISA, WB, DB | Mouse IgG |
| MRO-0876-CN | Mouse Anti-IDH1 Recombinant Antibody (clone A11-B4) | WB, IHC | Mouse IgG1 |
| VS3-FY721 | Recombinant Rabbit Anti-IDH1 Antibody (clone R05-2G5) | WB, IHC-P, IP | Rabbit IgG |
| VS7-0425-WR112 | Mouse Anti-IDH1 Recombinant Antibody (clone 4A4A8) | WB, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1733 | Rabbit Anti-IDH1 Recombinant Antibody (clone DS1733AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0136-YC-S(P) | Mouse Anti-IDH1 Recombinant Antibody (clone A2E8); scFv Fragment | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0136-YC-F(E) | Mouse Anti-IDH1 Recombinant Antibody (clone A2E8); Fab Fragment | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY268 | Mouse Anti-NHP IDH1 Recombinant Antibody (clone OTI24A2) | WB, IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1087 | Anti-IDH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3383 | Anti-Mouse IDH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3382 | Anti-Human IDH1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3384 | Anti-Rat IDH1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC24 | Anti-IDH1 Antibody Prodrug, Protease Activated (A2E8) | ISZ, Cyt, FuncS |
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