Mouse Anti-IFNB1 Recombinant Antibody (VS3-CJ264)
CAT#: VS3-CJ264
This product is a mouse antibody that recognizes IFNB1.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171855-IFNB1
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Specifications
- Immunogen
- Recombinant protein between 1-187 amino acids from human IFNB1
- Host Species
- Mouse
- Specificity
- Human IFNB1
- Species Reactivity
- Human
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Preservative
- 0.09% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:2000).
Target
- Alternative Names
- Interferon beta; IFN-beta; Fibroblast interferon; IFNB1; IFB; IFNB
- Gene ID
- 3456
- UniProt ID
- P01574
- Sequence Similarities
- Belongs to the alpha/beta interferon family.
- Cellular Localization
- Secreted
- Protein Refseq
- NP_002167.1
- Function
- Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:6157094, PubMed:6171735, PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041).
Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041).
Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity).
Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity).
Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity).
IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "IFNB1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1137z | Mouse Anti-IFNB1 Recombinant Antibody (clone 19C7) | ELISA, WB, FC | Mouse IgG1, κ |
| MOB-0956CT | Recombinant Mouse anti-Human IFNB1 Monoclonal antibody (C-03) | ELISA, Neut | |
| NEUT-985CQ | Mouse Anti-Ifnb1 Recombinant Antibody (clone HDβ-4A7) | ELISA, Block | Mouse IgG2a |
| HPAB-M0534-YC | Human Anti-IFNB1 Recombinant Antibody (HPAB-M0534-YC) | ELISA, Neut, Inhib, FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-962CQ | Mouse Anti-IFNB1 Recombinant Antibody (clone 7K51) | Neut, WB | Mouse IgG1 |
| NEUT-978CQ | Mouse Anti-IFNB1 Recombinant Antibody (clone A1 (IFNb)) | FuncS, Neut | Mouse IgG1, κ |
| NEUT-979CQ | Mouse Anti-IFNB1 Recombinant Antibody (VMC186) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-980CQ | Mouse Anti-IFNB1 Recombinant Antibody (NEUT-980CQ) | Neut | Mouse IgG2a |
| NEUT-981CQ | Mouse Anti-IFNB1 Recombinant Antibody (clone MM0760-32R25) | WB, Neut, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1741 | Rabbit Anti-IFNB1 Recombinant Antibody (clone DS1741AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0534-YC-S(P) | Human Anti-IFNB1 Recombinant Antibody; scFv Fragment (HPAB-M0534-YC-S(P)) | ELISA, Neut, Inhib, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0534-YC-F(E) | Human Anti-IFNB1 Recombinant Antibody; Fab Fragment (HPAB-M0534-YC-F(E)) | ELISA, Neut, Inhib, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY165 | Human Anti-IFNB1 scFv-Fc Chimera (VS-0425-FY165) | ELISA, Neut | Human IgG1, scFv-Fc |
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