Human Anti-IFNB1 scFv-Fc Chimera (VS-0425-FY165)
CAT#: VS-0425-FY165
Anti-IFNB1 scFv-FC refers to a specialized recombinant protein designed to bind specifically to Interferon Beta 1 (IFNB1), a critical cytokine used in the treatment of various autoimmune diseases, particularly multiple sclerosis. The scFv-FC format combines a single-chain variable fragment (scFv) of an antibody with the Fc region of an immunoglobulin, providing enhanced stability and a longer half-life in circulation.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171855-IFNB1
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IFNB1
- Species Reactivity
- Human, Cynomolgus
- Applications
- ELISA, Neutralization
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interferon Beta 1
- Gene ID
- 3456
- UniProt ID
- P01574
- Long Name
- Interferon Beta 1
- Sequence Similarities
- Belongs to the alpha/beta interferon family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn101
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect IFNB_HUMAN (291)
Glycosylation from GlyGen 2 sites, 2 N-linked glycans (2 sites)
- Protein Refseq
- NP_002167.1
- Function
- Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli.
Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins.
Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.
Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IFNB1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1137z | Mouse Anti-IFNB1 Recombinant Antibody (clone 19C7) | ELISA, WB, FC | Mouse IgG1, κ |
| MOB-0956CT | Recombinant Mouse anti-Human IFNB1 Monoclonal antibody (C-03) | ELISA, Neut | |
| NEUT-985CQ | Mouse Anti-Ifnb1 Recombinant Antibody (clone HDβ-4A7) | ELISA, Block | Mouse IgG2a |
| HPAB-M0534-YC | Human Anti-IFNB1 Recombinant Antibody (HPAB-M0534-YC) | ELISA, Neut, Inhib, FuncS | Humanized IgG |
| VS3-CJ264 | Mouse Anti-IFNB1 Recombinant Antibody (VS3-CJ264) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-962CQ | Mouse Anti-IFNB1 Recombinant Antibody (clone 7K51) | Neut, WB | Mouse IgG1 |
| NEUT-978CQ | Mouse Anti-IFNB1 Recombinant Antibody (clone A1 (IFNb)) | FuncS, Neut | Mouse IgG1, κ |
| NEUT-979CQ | Mouse Anti-IFNB1 Recombinant Antibody (VMC186) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-980CQ | Mouse Anti-IFNB1 Recombinant Antibody (NEUT-980CQ) | Neut | Mouse IgG2a |
| NEUT-981CQ | Mouse Anti-IFNB1 Recombinant Antibody (clone MM0760-32R25) | WB, Neut, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1741 | Rabbit Anti-IFNB1 Recombinant Antibody (clone DS1741AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0534-YC-S(P) | Human Anti-IFNB1 Recombinant Antibody; scFv Fragment (HPAB-M0534-YC-S(P)) | ELISA, Neut, Inhib, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0534-YC-F(E) | Human Anti-IFNB1 Recombinant Antibody; Fab Fragment (HPAB-M0534-YC-F(E)) | ELISA, Neut, Inhib, FuncS | Humanized Fab |
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