Human Anti-IFNB1 scFv-Fc Chimera (VS-0425-FY165) (CAT#: VS-0425-FY165)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human IFNB1

• Species Reactivity
• Human, Cynomolgus

• Applications
• ELISA, Neutralization

• Related Disease
• Autoimmune disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Interferon Beta 1

• Gene ID
• 3456

• UniProt ID
• P01574

• Long Name
• Interferon Beta 1

• Sequence Similarities
• Belongs to the alpha/beta interferon family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn101
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect IFNB_HUMAN (291)
  Glycosylation from GlyGen 2 sites, 2 N-linked glycans (2 sites)

• Protein Refseq
• NP_002167.1

• Function
• Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli.
  Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins.
  Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.
  Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor.

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