Mouse Anti-IGF1 Recombinant Antibody (clone MuEM164) (CAT#: HPAB-646-FY)
This product is a recombinant antibody that recognizes IGF1. The monoclonal antibody MuEM164 reacts with the epitope of IGF1. The inhibition of IGF-I-stimulated IRS-1-phosphorylation in MCF-7 cells by EM164 antibody.
Specific Inquiry
FC
Figure 1 Shows fluorescence activated cell sorting (FACS) analysis of the specific binding of purified EM164 antibody to cells overexpressmg human Y1251F IGF-I receptor or human insulin receptor.
ELISA
Figure 2 Shows a binding titration curve for the binding of EMI 64 antibody to biotinylated human IGF-I receptor.
Inhib
Figure 3 Shows the effect of treatment with EM164 antibody, taxol, or a combination of EMI 64 antibody and taxol, on the growth of a Calu-6 lung cancer xenograft in mice.
Inhib
Figure 4 Shows the inhibition of IGF-I-stimulated signal transduction in SaOS-2 cells by EMI 64 antibody.
Cyt
Figure 5 Shows that EMI 64 suppresses the anti-apoptotic effect of IGF-I and serum.
Treatment with EMI 64 results in apoptotic cell death as demonstrated by the increased levels of cleaved CK18 protein.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human IGF1
- Species Reactivity
- Human
- Clone
- MuEM164
- Applications
- FC, ELISA, Inhib, Cyt
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IGF1 antibody has been reported in applications of Flow Cytometry, Enzyme-linked Immunosorbent Assay, Inhibition, Cytotoxicity.
Target
Related Resources
Insulin Signaling Pathway
Endocrine Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
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Fab Antibody Products
MHC Tetramer Products for Cancer
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-385CL | Anti-Human IGF1 Recombinant Antibody (TAB-385CL) | WB, FuncS | Antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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