Mouse Anti-IGF1 Recombinant Antibody (clone MuEM164)
CAT#: HPAB-646-FY
This product is a recombinant antibody that recognizes IGF1. The monoclonal antibody MuEM164 reacts with the epitope of IGF1. The inhibition of IGF-I-stimulated IRS-1-phosphorylation in MCF-7 cells by EM164 antibody.
Published Data
Gene Expression
FC
Figure 1 Shows fluorescence activated cell sorting (FACS) analysis of the specific binding of purified EM164 antibody to cells overexpressmg human Y1251F IGF-I receptor or human insulin receptor.
ELISA
Figure 2 Shows a binding titration curve for the binding of EMI 64 antibody to biotinylated human IGF-I receptor.
Inhib
Figure 3 Shows the effect of treatment with EM164 antibody, taxol, or a combination of EMI 64 antibody and taxol, on the growth of a Calu-6 lung cancer xenograft in mice.
Inhib
Figure 4 Shows the inhibition of IGF-I-stimulated signal transduction in SaOS-2 cells by EMI 64 antibody.
Cyt
Figure 5 Shows that EMI 64 suppresses the anti-apoptotic effect of IGF-I and serum.
Treatment with EMI 64 results in apoptotic cell death as demonstrated by the increased levels of cleaved CK18 protein.
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Normal Tissue
Figure 1 IHC staining of human colon
Immunohistochemical staining of human colon shows plasma positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
Normal Tissue
Figure 3 Rectum
Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, HDLM-2, K-562, Karpas-707, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human IGF1
- Species Reactivity
- Human
- Clone
- MuEM164
- Applications
- FC, ELISA, Inhib, Cyt
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IGF1 antibody has been reported in applications of Flow Cytometry, Enzyme-linked Immunosorbent Assay, Inhibition, Cytotoxicity.
Target
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Related Signaling Pathways
Insulin Signaling Pathway
Related Diseases
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1353z | Mouse Anti-IGF1 Recombinant Antibody (clone 23C1) | FC, IF, Neut | Mouse IgG1, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-385CL | Anti-Human IGF1 Recombinant Antibody (TAB-385CL) | WB, FuncS | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1072CQ | Mouse Anti-IGF1 Recombinant Antibody (clone M23) | Neut, FC, ICC, IF | Mouse IgG1, κ |
| NEUT-1073CQ | Mouse Anti-IGF1 Recombinant Antibody (clone SPM406) | WB, Neut, FC, ICC, IF, IHC-P, IP | Mouse IgG1, κ |
| NEUT-1074CQ | Hamster Anti-Igf1 Recombinant Antibody (clone CBL534) | WB, ELISA, Neut | Hamster IgG |
| CAT | Product Name | Application | Type |
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| MOR-1754 | Rabbit Anti-IGF1 Recombinant Antibody (clone DS1754AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-YC-S(P) | Mouse Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0038-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-0039-YC-S(P) | Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0039-YC-S(P)) | ELISA, Stim, Neut | Human scFv |
| HPAB-646-FY-S(P) | Mouse Anti-IGF1 Recombinant Antibody (clone MuEM164); scFv Fragment | Inhib, FC | Mouse scFv |
| HPAB-647-FY-S(P) | Human Anti-IGF1 Recombinant Antibody (clone huEM164 V1.0); scFv Fragment | Inhib, FC | Human scFv |
| HPAB-0160-YJ-S(P) | Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0160-YJ-S(P)) | ELISA, Neut, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0771-CN-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0771-CN-F(E)) | WB, FC | Human Fab |
| HPAB-0038LY-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0038LY-F(E)) | WB | Human Fab |
| HPAB-646-FY-F(E) | Mouse Anti-IGF1 Recombinant Antibody (clone MuEM164); Fab Fragment | Inhib, FC | Mouse Fab |
| HPAB-647-FY-F(E) | Human Anti-IGF1 Recombinant Antibody (clone huEM164 V1.0); Fab Fragment | Inhib, FC | Human Fab |
| HPAB-0711-FY-S(P) | Mouse Anti-IGF1 Recombinant Antibody (clone AB010); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0897 | PE-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC | |
| MHC-CN0898 | APC-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC | |
| MHC-CN0899 | FITC-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC | |
| MHC-CN0900 | H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY73 | Human Anti-IGF1 (clone Cixutumumab) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3427 | Anti-IGF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3428 | Anti-Mouse IGF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3429 | Anti-Rabbit IGF1 Immunohistochemistry Kit | IHC |
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