Rabbit Anti-KDM5A Recombinant Antibody (clone R02-3F8)
CAT#: VS3-XY3406
This is a recombinant rabbit antibody that specifically recognizes human KDM5A (Lysine demethylase 5A), which plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. It also has cross-reactivity against mouse KDM5A. It has been reported for use in Western Blot, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear bodies & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6201/43_F7_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000073614-KDM5A
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse KDM5A
- Species Reactivity
- Human, Mouse
- Clone
- R02-3F8
- Applications
- WB, ICC, IF, IP, FC
- Related Disease
- Retinoblastoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- RBP2; RBBP2; RBBP-2
- Gene ID
- 5927
- UniProt ID
- P29375
- Long Name
- Lysine demethylase 5A
- Cellular Localization
- Nucleus, nucleolus
- Post Translation Modifications
- Ubiquitination at Lys347, Lys425, Lys733, and Lys1275 (NX_P29375 [NX_P29375-1])
Modification sites at PhosphoSitePlus (P29375)
Glycosylation from GlyGen (P29375) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001036068.1
- Function
- Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code.
Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'.
Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.
Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "KDM5A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1432MZ | Recombinant Mouse Anti-Human KDM5A Antibody (clone 29F9) | WB | Mouse antibody |
| MRO-0896-CN | Recombinant Rabbit Anti-KDM5A Monoclonal Antibody (JB36-60) | WB, IF, FC | Rabbit IgG |
| VS3-WK289 | Rabbit Anti-KDM5A Recombinant Antibody (clone JB36-60) | WB, ELISA | Rabbit IgG |
| VS3-CJ50 | Mouse Anti-KDM5A Recombinant Antibody (VS3-CJ50) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1925 | Hi-Affi™ Recombinant Rabbit Anti-KDM5A Monoclonal Antibody (DS1925AB) | FC, WB | IgG |
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