Mouse Anti-LRP1 Recombinant Antibody (clone 1C8G6)
CAT#: VS7-0425-WR309
This product is a mouse IgG1 antibody that binds to human LRP1. The antibody 1C8G6 recognizes specific amino acid domain of human LRP1 (AA: 20-155). It can be used for IHC and ICC assays.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4182/1150_F4_7_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4182/13067_A_2_7_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18621/41781_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Fibroblasts
Staining: High
Intensity: Strong
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18621/41781_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18621/41781_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22903/51316_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18621/41781_A_4_6.jpg
Normal Tissue
Figure 8 Soft tissue
Fibroblasts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18621/41781_B_2_8.jpg
Normal Tissue
Figure 9 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18621/41781_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123384-LRP1
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Specifications
- Immunogen
- Recombinant human LRP1 (AA: 20-155) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human LRP1
- Species Reactivity
- Human
- Clone
- 1C8G6
- Molecule Class
- Low-Density Lipoprotein Receptor (LDLR)
- Applications
- IHC, ICC
- Conjugate
- Unconjugated
- Related Disease
- Keratosis pilaris atrophicans (KPA); Developmental dysplasia of the hip 3 (DDH3)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunohistochemistry-Paraffin: 1:200 - 1:1000
Immunocytochemistry: 1:200 - 1:1000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- LRP1; low density lipoprotein receptor-related protein 1; APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin recepto
- Gene ID
- 4035
- UniProt ID
- Q07954
- Long Name
- LDL receptor related protein 1
- Cellular Localization
- Cell membrane; Coated pit; Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane; Nucleus
- Post Translation Modifications
- Acetylation; Disulfide bond; Glycoprotein; Phosphoprotein
- Protein Refseq
- NP_002323.2
- Function
- Developmental protein; Receptor
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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