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    LRP1

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    Anti-LRP1 Products

    • RAP-DT immunotoxin (AGTO-L081D)
      • Species Reactivity: Human
      • Application: Cytotoxicity assay, Functional assay
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    • RAP-PE immunotoxin (AGTO-L081E)
      • Species Reactivity: Human
      • Application: Cytotoxicity assay, Functional assay
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
    Protein class

    Candidate cardiovascular disease genes, CD markers, Disease related genes, Plasma proteins, Potential drug targets, Transporters

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Fibroblasts, Leydig cells, Hepatocytes, Peritubular cells)

    Immune cell specificity

    Group enriched (classical monocyte, non-classical monocyte, intermediate monocyte, myeloid DC)

    Cell line specificity

    Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC, hTERT-RPE1)

    Interaction

    Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI (PubMed:17124247). Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Can weakly interact (via NPXY motif) with DAB2 (via PID domain); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif. Interacts with MDK; promotes neuronal survival (PubMed:10772929). Interacts with LRPAP1; this interaction is followed by rapid internalization (PubMed:15053742, 32296178, 16938309). Interacts with uPA/PLAU and PAI1/SERPINE1, either individually or in complex with each other, leading to rapid endocytosis; this interaction is abolished in the presence of LRPAP1/RAP (PubMed:15053742). Also interacts with tPA/PLAT alone or in complex with SERPINE1 (PubMed:15053742). Interacts with the urokinase receptor PLAUR; this interaction leads to PLAUR internalization and is impaired in the presence of SORL1 (PubMed:14764453). Interacts with PDGFB (PubMed:15053742). Interacts with TAU/MAPT, leading to endocytosis; this interaction is reduced in the presence of LRPAP1/RAP (PubMed:32296178). (Microbial infection) Interacts with bacterial exotoxins. (Microbial infection) Interacts with Rift valley fever virus (RVFV) glycoprotein N; this interaction facilitates virus entry.

    Molecular function

    Developmental protein, Receptor

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